Trametinib-13C-d3 CAS 2712126-59-3
| CAS No. | 2712126-59-3 |
| Molecular Formula | C25[13C]H20D3FIN5O4 |
| Molecular Weight | 619.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Trametinib-13C-d3 (CAS 2712126-59-3), a certified reference material (molecular formula C25[13C]H20D3FIN5O4, MW 619.41 g/mol) for analytical method development and quality control.
Structurally, Trametinib-13C-d3 (C25[13C]H20D3FIN5O4) contains deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.5, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 619.41 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Trametinib-13C-d3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25[13C]H20D3FIN5O4 |
| Molecular Weight | 619.41 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 5 |
Related Trametinib Standards
- Trametinib impurity 26 (CAS CATO-C4X-27826)
- Trametinib impurity 04 (CAS 871700-25-3)
- Trametinib Impurity N11 (CAS 871701-23-4)
- Trametinib (CAS 871700-17-3)
- Trametinib Impurity N2 (CAS 871701-39-2)
- Trametinib impurity 18 (CAS 1383430-03-2)
- Trametinib Impurity 12 (CAS 1279693-89-8)
- Trametinib impurity 02 (CAS 871700-32-2)
Recommended Standards
- (1S,2S)-(+)-[1,2-Cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]aluminum(III) chloride 307926-51-8 (S,S)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,2-CYCLOHEXANEDIAMINOALUMINUM CHLORIDE;(S,S)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,2-CYCLOHEXANEDIAMINOALUMINUM(III) CHLORIDE;(1S,2S)-(+)-[1,2-Cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]aluminum(III) chloride SC10791 (CAS 307926-51-8)
- Lifitegrast Impurity 85 (CAS CATO-C4X-240985)
- (1R,2R)-(-)-[1,2-Cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]aluminum(III) chloride 250611-13-3 (R,R)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,2-CYCLOHEXANEDIAMINOALUMINIUM(III) CHLORIDE;(R,R)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,2-CYCLOHEXANEDIAMINOALUMINUM CHLORIDE;(R,R)-N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDINE)-1,2-CYCLOHEXANEDIAMINO-ALUMINUM(III) CHLORIDE;(1R,2R)-(-)-[1,2-Cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]aluminum(III) chloride SC10790 (CAS 250611-13-3)
- Lifitegrast Impurity 86 (CAS CATO-C4X-240986)
- 6-(Benzyloxy)-5-nitronicotinic acid (CAS 1508309-21-4)
- 3-{4-[(3-Fluorobenzyl)oxy]phenyl}acrylic acid (CAS 423752-10-7)
- (11E,13E)-11,13-Hexadecadienal (CAS 73264-91-2)
- 2,3-Dibromo-3-(2-bromophenyl)propionic Acid (CAS 119450-03-2)
- (3Z)-3-{[(4-phenoxyphenyl)amino]methylidene}-1,3-dihydro-2-benzothiophen-1-one (CAS 338954-43-1)
- 5-(1-(8-Bromo-6-fluoroquinazolin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (CAS 1351499-86-9)
- 6-mercaptopyridine-3-sulfonamide (CAS 10298-20-1)
- 2-(Cyclohexylamino)propan-1-ol (CAS 27840-90-0)
- Carglumic Acid Impurity 15 (CAS CATO-C4X-207915)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com