Trametinib Impurity N2 CAS 871701-39-2
| CAS No. | 871701-39-2 |
| Molecular Formula | C26H23FIN5O5 |
| Molecular Weight | 631.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trametinib Impurity N2.
Trametinib Impurity N2 (CAS 871701-39-2) is a certified pharmaceutical impurity reference standard with the molecular formula C26H23FIN5O5 and a molecular weight of 631.39 g/mol.
The molecular framework of Trametinib Impurity N2 (C26H23FIN5O5) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Trametinib Impurity N2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H23FIN5O5 |
| Molecular Weight | 631.39 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 5 |
Related Trametinib Standards
- Trametinib impurity 18 (CAS 1383430-03-2)
- Trametinib impurity 02 (CAS 871700-32-2)
- Trametinib Impurity 19 (CAS CATO-C4X-278219)
- Trametinib impurity 26 (CAS CATO-C4X-27826)
- Trametinib-13C-d3 (CAS 2712126-59-3)
- Trametinib impurity 04 (CAS 871700-25-3)
- Trametinib Impurity N10 (CAS 1383430-04-3)
- Trametinib Impurity N11 (CAS 871701-23-4)
Recommended Standards
- Reactive Orange 14 (CAS 12225-86-4)
- rac-1,2-Dilinolenoyl-3-chloropropanediol (CAS 74875-97-1)
- tert-Butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate (CAS 1415559-49-7)
- Titanium(IV) phthalocyanine dichloride (CAS 16903-42-7)
- Sitafloxacin Impurity 32 (CAS CATO-C4X-115532)
- Empagliflozin Impurity 305 (CAS CATO-C4X-1065305)
- Elacestrant Impurity 7 (CAS CATO-C4X-32327)
- 4-Methyl-4-nitropentanoic acid (CAS 32827-16-0)
- 1-([2,4'-Bipiperidin]-1-yl)-2-(2-fluorophenyl)ethan-1-one (CAS 1316217-38-5)
- 2-Chlorobutanenitrile (CAS 4158-37-6)
- 4-Ethyl-6-isopropyl-2-oxo-2H-chromene-3-carbonitrile (CAS 1352522-18-9)
- 2-((3-Cyano-6-methylpyridin-2-yl)thio)acetamide (CAS 317324-71-3)
- 5-(3-Methoxyphenyl)-1-pentene (CAS 40463-20-5)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com