Trametinib impurity 02 CAS 871700-32-2
| CAS No. | 871700-32-2 |
| Molecular Formula | C25H21FIN3O6S |
| Molecular Weight | 637.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Trametinib impurity 02 (CAS 871700-32-2, C25H21FIN3O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Trametinib impurity 02 (C25H21FIN3O6S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 637.42 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C25H21FIN3O6S |
| Molecular Weight | 637.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Trametinib Standards
- Trametinib Impurity 19 (CAS CATO-C4X-278219)
- Trametinib Impurity N2 (CAS 871701-39-2)
- Trametinib impurity 18 (CAS 1383430-03-2)
- Trametinib Impurity N10 (CAS 1383430-04-3)
- Trametinib impurity 26 (CAS CATO-C4X-27826)
- Trametinib-13C-d3 (CAS 2712126-59-3)
- Trametinib impurity 04 (CAS 871700-25-3)
- Trametinib Impurity N11 (CAS 871701-23-4)
Recommended Standards
- 2,3,9,10,16,17-Hexachlorinated boron subphthalocyanine chloride (CAS 309963-65-3)
- 2'/3'-O-Trinitrophenyl-adenosine-5'-diphosphate (CAS 77450-67-0)
- rac 1-Oleoyl-2-linoleoyl-3-chloropropanediol (CAS 1336935-03-5)
- 3-(2-(4-Hydroxy-3,5-diiodostyryl)-3,3-dimethyl-3H-indol-1-ium-1-yl)propane-1-sulfonate (CAS 145876-11-5)
- Bupropion Impurity 44 (CAS 357628-62-7)
- Ambrisentan Impurity N1 (CAS 1312092-82-2)
- Pioglitazone EP Impurity E (CAS 868754-42-1)
- 5-Cyclopropoxy-4-methoxy-N-methylpicolinamide (CAS 1243363-33-8)
- 2-Chloro-4-methoxy-6-phenoxy-1,3,5-triazine (CAS 42030-98-8)
- 2-(Isoquinolin-3-yl)ethan-1-ol (CAS 69529-10-8)
- N-(Methoxy(phenyl)methyl)benzamide (CAS 10387-93-6)
- 4-(tert-Butoxy)-2-cyclopropoxy-1-methylbenzene (CAS 1243410-96-9)
- tert-Butyl (1-(6-(diethylamino)pyrimidin-4-yl)piperidin-3-yl)(methyl)carbamate (CAS 1353987-99-1)
- Human glucagon CRS (CAS 9007-92-5)
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