Trametinib impurity 04 CAS 871700-25-3
| CAS No. | 871700-25-3 |
| Molecular Formula | C26H23FIN5O4 |
| Molecular Weight | 615.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Trametinib impurity 04 (CAS 871700-25-3), a pharmacopoeial impurity reference standard (molecular formula C26H23FIN5O4, MW 615.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Trametinib impurity 04 (C26H23FIN5O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 615.39 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Trametinib impurity 04 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H23FIN5O4 |
| Molecular Weight | 615.39 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 5 |
Related Trametinib Standards
- Trametinib Impurity N11 (CAS 871701-23-4)
- Trametinib (CAS 871700-17-3)
- Trametinib-13C-d3 (CAS 2712126-59-3)
- Trametinib impurity 26 (CAS CATO-C4X-27826)
- Trametinib Impurity 12 (CAS 1279693-89-8)
- Trametinib Impurity N2 (CAS 871701-39-2)
- Trametinib impurity 18 (CAS 1383430-03-2)
- Trametinib impurity 02 (CAS 871700-32-2)
Recommended Standards
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