Ibrutinib Impurity 3 CAS 1288338-96-4
| CAS No. | 1288338-96-4 |
| Molecular Formula | C25H25ClN6O2 |
| Molecular Weight | 476.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Ibrutinib Impurity 3 (CAS 1288338-96-4, C25H25ClN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ibrutinib Impurity 3 (C25H25ClN6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Ibrutinib Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H25ClN6O2 |
| Molecular Weight | 476.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 31 (CAS CATO-C4X-106431)
- Ibrutinib Impurity 92 (CAS CATO-C4X-106492)
- Ibrutinib Impurity 93 (CAS CATO-C4X-106493)
- Ibrutinib Impurity 13 (Mixture of Diastereomers) (CAS 1654820-87-7)
- Ibrutinib Impurity 137 (CAS CATO-C4X-1064137)
- Ibrutinib Impurity 160 (CAS CATO-C4X-1064160)
- Ibrutinib Impurity 169 (CAS CATO-C4X-1064169)
- Ibrutinib Impurity 44 (CAS 2031255-26-0)
Recommended Standards
- tert-Butyl 4-[6-(4-chlorophenyl)-5-cyano-2-(pyridin-4-yl)pyrimidin-4-yl]piperazine-1-carboxylate (CAS 383148-76-3)
- (E)-N'-((3-([1,1'-biphenyl]-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-chlorobenzohydrazide (CAS 956211-82-8)
- Methyl 5-((3-chlorophenyl)carbamoyl)-2-((5,6-dimethyl-2H-pyran-2-yl)(ethoxy)amino)-4-methylthiophene-3-carboxylate (CAS 505096-40-2)
- Janagliflozin impurity 2 (CAS CATO-C4X-30322)
- Lidocaine Impurity 39 (CAS 77966-82-6)
- Mesalazine Impurity 32 (CAS CATO-C4X-132432)
- Famciclovir Impurity 7 (CAS 2815212-98-5)
- 4-Hydroxytetrahydro-2H-pyran-2-carboxylic acid (CAS 854695-96-8)
- 7393-43-3 Stannane, tetra-2-propenyl- Tetrallylstannane AI3-28455 EINECS 230-987-5 (CAS 7393-43-3)
- (E)-N'-(1-(Benzofuran-2-yl)-2,2,2-trifluoroethylidene)-2-(trifluoromethyl)benzenesulfonohydrazide (CAS 2759078-42-5)
- Methyl 2-(3,4-dihydro-2H-pyrrol-5-yl)hydrazine-1-carboxylate (CAS 1306753-54-7)
- n-[4-(1-aminoethyl)phenyl]pyridine-4-carboxamide (CAS 544694-70-4)
- Furosemide Impurity 55 (CAS 76852-02-3)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com