Sildenafil impurity 264 CAS 2725318-34-1
| CAS No. | 2725318-34-1 |
| Molecular Formula | C22H26N2O10S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Sildenafil impurity 264 (CAS 2725318-34-1) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26N2O10S2C8H19N and a molecular weight of 671.82 g/mol.
Structurally, Sildenafil impurity 264 (C22H26N2O10S2C8H19N) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 671.82 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O10S2 C8H19N |
| Molecular Weight | 671.82 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Sildenafil Standards
- Sildenafil Impurity N6 (CAS 1004455-71-3)
- Sildenafil Impurity 258 (CAS 1007310-62-4)
- Sildenafil Impurity 256 (CAS 1027192-9-2)
- Sildenafil Impurity 5 (CAS 1058653-74-9)
- Sildenafil Impurity 29 (CAS 1093065-15-6)
- Sildenafil EP Impurity B (CAS 1094598-75-0)
- Sildenafil-D3 (CAS 1126745-90-1)
- Sildenafil Impurity 62 (CAS 116833-23-9)
Recommended Standards
- Loratadine EP Impurity A (CAS 133284-74-9)
- Gadobutrol Impurity 143 4HCl (CAS CATO-C4X-2120143)
- Etoposide Impurity 34 (CAS CATO-C4X-202434)
- methyl 3-amino-5-(methoxymethyl)benzoate (CAS 1310105-53-3)
- 2-(1-(4-Methoxyphenyl)cyclopropyl)acetic acid (CAS 1225503-00-3)
- 3,4-Dibromo-5-methoxyaniline (CAS 95970-21-1)
- 2-(4-Aminopiperidin-1-yl)isonicotinic acid (CAS 1247650-36-7)
- 2-Chloro-3-[(2,5-dimethoxyphenyl)amino]-1,4-dihydronaphthalene-1,4-dione (CAS 331462-39-6)
- 2-Fluoro-6-phenoxybenzonitrile (CAS 175204-06-5)
- Peptide 434 (CAS CATO-CPTD788434)
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