Lenvatinib Impurity 42 CAS 2733083-03-7
| CAS No. | 2733083-03-7 |
| Molecular Formula | C18H14ClN3O5 |
| Molecular Weight | 387.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lenvatinib Impurity 42 (CAS 2733083-03-7) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14ClN3O5 and a molecular weight of 387.77 g/mol.
Lenvatinib Impurity 42 (C18H14ClN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14ClN3O5 |
| Molecular Weight | 387.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lenvatinib Standards
- Lenvatinib Impurity 87 (CAS CATO-C4X-114087)
- Lenvatinib Impurity 3 (CAS 417719-51-8)
- Lenvatinib Impurity 173 (CAS CATO-C4X-1140173)
- Lenvatinib Impurity 41 (CAS CATO-C4X-114041)
- Lenvatinib Impurity 1 (CAS 417714-14-8)
- Lenvatinib Impurity 4 (CAS 417719-45-0)
- Lenvatinib Impurity 172 (CAS CATO-C4X-1140172)
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
Recommended Standards
- 5-{[5-chloro-2-(methoxycarbonyl)phenyl]sulfamoyl}-2-fluorobenzoic acid (CAS 949760-08-1)
- 4-(3-(2-Chloro-4-nitrobenzyl)ureido)benzene-1-sulfonyl fluoride (CAS 21322-84-9)
- 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-N-(3-methoxybenzyl)propanamide (CAS 1376308-87-0)
- 2-Chloro-4-nitrobenzyl 3-(3-hydroxyquinoxalin-2-yl)propanoate (CAS 831249-87-7)
- Avatrombopag Impurity 61 (CAS CATO-C4X-223461)
- Naloxone Hydrochloride EP Impurity C (CAS 2139253-68-0)
- Promethazine Impurity 52 (CAS CATO-C4X-141852)
- 2-((4-Fluorophenyl)amino)pyrimidin-4(3H)-one (CAS 1201791-24-3)
- (S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide (CAS 196597-86-1)
- N-(2,5-dimethoxybenzyl)-1-(pyridin-3-yl)methanamine (CAS 626205-85-4)
- 22,23-Didehydro Selamectin (CAS 165108-09-8)
- 7-Chloro-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazine (CAS 1259513-96-6)
- 2-(3-(3-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)acetic acid (CAS 75821-67-9)
- Semaglutide impurity 77 (CAS CATO-C4X-222677)
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