Lenvatinib Impurity 3 CAS 417719-51-8
| CAS No. | 417719-51-8 |
| Molecular Formula | C18H15ClN4O4 |
| Molecular Weight | 386.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lenvatinib Impurity 3 (CAS 417719-51-8) is a certified pharmaceutical impurity reference standard with the molecular formula C18H15ClN4O4 and a molecular weight of 386.79 g/mol.
Based on its molecular formula C18H15ClN4O4, Lenvatinib Impurity 3 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 386.79 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15ClN4O4 |
| Molecular Weight | 386.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 42 (CAS 2733083-03-7)
- Lenvatinib Impurity 87 (CAS CATO-C4X-114087)
- Lenvatinib Impurity 173 (CAS CATO-C4X-1140173)
- Lenvatinib Impurity 41 (CAS CATO-C4X-114041)
- Lenvatinib Impurity 1 (CAS 417714-14-8)
- Lenvatinib Impurity 4 (CAS 417719-45-0)
- Lenvatinib Impurity 172 (CAS CATO-C4X-1140172)
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
Recommended Standards
- Quazepam (CAS 36735-22-5)
- Roxadustat Impurity 14 (CAS 808119-86-0)
- Methyl 4-(3-chlorophenoxy)-1-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxylate (CAS 338405-43-9)
- Roxadustat Impurity 24 (CAS CATO-C4X-221324)
- Betamethasone impurity 63 (CAS CATO-C4X-143763)
- Alprazolam EP Impurity H (CAS 2203515-05-1)
- Flumazenil EP Impurity D (CAS 78755-80-3)
- tert-Butyl 5-(hydroxymethyl)isoindoline-2-carboxylate (CAS 253801-14-8)
- Fibrinopeptide A (human) (CAS 25422-31-5)
- tert-butyl cis-2,5-dimethylpiperazine-1-carboxylate (CAS 194032-43-4)
- 3-[2-(Morpholin-4-yl)ethyl]-3,4-dihydro-1,2,3-benzotriazin-4-one (CAS 854161-41-4)
- (tert-butyldimethylsiloxy)acetaldehyde (CAS 102191-92-4)
- 2-(Difluoromethoxy)-4-methylaniline hydrochloride (CAS 1431962-99-0)
- Peptide Impurity 28 (CAS 1350456-64-2)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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