Eltrombopag Impurity 101 CAS 2750368-89-7
| CAS No. | 2750368-89-7 |
| Molecular Formula | C36H38N6O3 |
| Molecular Weight | 602.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Eltrombopag Impurity 101.
Eltrombopag Impurity 101 (CAS 2750368-89-7) is a certified pharmaceutical impurity reference standard with the molecular formula C36H38N6O3 and a molecular weight of 602.73 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Eltrombopag Impurity 101 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 602.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H38N6O3 |
| Molecular Weight | 602.73 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 6 |
Related Eltrombopag Standards
- Eltrombopag Impurity 78 (CAS CATO-C4X-119878)
- Eltrombopag Acyl Glucuronide (CAS CATO-C4X-1198121)
- Eltrombopag Impurity 70 (CAS CATO-C4X-119870)
- Eltrombopag Impurity 90 (CAS CATO-C4X-119890)
- Eltrombopag impurity 148 (CAS CATO-C4X-1198148)
- Eltrombopag Impurity 80 (CAS CATO-C4X-119880)
- Eltrombopag Impurity 27 (CAS CATO-C4X-119827)
- Eltrombopag Impurity 29 (CAS CATO-C4X-119829)
Recommended Standards
- Deferoxamine Mesylate Impurity 3 (CAS 5722-48-5)
- 1-(2H-1,3-Benzodioxol-5-yl)-3-({4-[(4-{[3-(2H-1,3-benzodioxol-5-yl)-3-oxopropyl]sulfanyl}phenyl)sulfanyl]phenyl}sulfanyl)propan-1-one (CAS 882749-72-6)
- Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl] (CAS 133155-89-2)
- Benzylpenicillin Impurity 78 (CAS CATO-C4X-189978)
- Pramipexole Impurity 9 (CAS 104617-86-9)
- Ritonavir Impurity N11 (CAS 2519851-81-9)
- Promethazine Impurity 62 (CAS CATO-C4X-141862)
- Cefuroxime Axetil EP Impurity D (CAS 55268-75-2)
- N-Isobutylcyclopropanamine Hydrochloride (CAS 1020353-46-1)
- Methyl 4-(2-oxo-2-((thiophen-3-ylmethyl)amino)acetamido)benzoate (CAS 1060349-47-4)
- Tert-butyl (S)-2-(2,3-dihydro-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (CAS 1374123-26-8)
- germanium dichloride-dioxane complex (CAS 10060-11-4)
- N-Isopropyl-4-(piperidin-3-ylmethoxy)benzamidehydrochloride (CAS 1332529-70-0)
- Prolactin-Releasing Peptide (12-31), rat (CAS 222988-10-5)
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