Sorafenib EP Impurity E CAS 284670-98-0
| CAS No. | 284670-98-0 |
| Molecular Formula | C27H24N6O5 |
| Molecular Weight | 512.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 512.52 g/mol gives Sorafenib EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Sorafenib EP Impurity E (CAS 284670-98-0, C27H24N6O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sorafenib EP Impurity E (C27H24N6O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H24N6O5 |
| Molecular Weight | 512.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Sorafenib Standards
- Sorafenib Impurity 36 (CAS CATO-C4X-112436)
- Sorafenib Impurity 39 (CAS CATO-C4X-112439)
- Sorafenib Impurity 22 (CAS 583840-03-3)
- Sorafenib Impurity 59 (CAS CATO-C4X-112459)
- Sorafenib Impurity 60 (CAS CATO-C4X-112460)
- Sorafenib-d3 (CAS 1130115-44-4)
- Sorafenib Related Compound 28 (CAS 583840-04-4)
- Sorafenib related compound 26 (CAS 573673-43-5)
Recommended Standards
- Diethyl 2-(((3-(3,4-dimethoxyphenethyl)-2,4-dioxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-yl)amino)methylene)malonate (CAS 900019-31-0)
- Fmoc-β-Ala-L-Arg(NO2)- OH (CAS CATO-CPTD788975)
- 1,4,5,8-Tetraamino-2,7-bis(4-methoxyphenoxy)anthracene-9,10-dione (CAS 88600-81-1)
- BAlq (CAS 146162-54-1)
- Betamethasone Dipropionate EP Impurity H (CAS 2575516-37-7)
- Tetracaine Impurity 10 (CAS 65213-46-9)
- Ceftezole Impurity 2 (CAS CATO-C4X-23092)
- N-(3-Amino-4-chlorophenyl)-3-chlorobenzamide (CAS 926243-94-9)
- Methyl 1-formylcyclohexanecarboxylate (CAS 84393-05-5)
- 2-(Cyclopropylmethoxy)propanoic acid (CAS 1019515-23-1)
- 3-((2-Oxo-2-(3-phenylisoxazol-5-yl)ethyl)thio)-4-(pyridin-3-yl)-1H-1,2,4-triazol-5(4H)-one (CAS 712270-97-8)
- 1-(4-Chlorophenyl)-4-methylpentan-1-amine (CAS 161531-24-4)
- 4-Chlorobenzyl (3-methoxythiophen-2-yl)carbamate (CAS 477845-97-9)
- Semaglutide Impurity 15 (CAS CATO-C4X-222615)
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