Sorafenib Impurity 22 CAS 583840-03-3
| CAS No. | 583840-03-3 |
| Molecular Formula | C21H16ClF3N4O4 |
| Molecular Weight | 480.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sorafenib Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Sorafenib Impurity 22 (CAS 583840-03-3, C21H16ClF3N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sorafenib Impurity 22 (C21H16ClF3N4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H16ClF3N4O4 |
| Molecular Weight | 480.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Sorafenib Standards
- Sorafenib Impurity 59 (CAS CATO-C4X-112459)
- Sorafenib-d3 (CAS 1130115-44-4)
- Sorafenib Related Compound 28 (CAS 583840-04-4)
- Sorafenib related compound 26 (CAS 573673-43-5)
- Sorafenib (Base) (CAS 284461-73-0)
- Sorafenib Impurity 40 (CAS 1290546-48-3)
- Sorafenib Impurity 42 (CAS CATO-C4X-112442)
- Sorafenib EP Impurity H (CAS 1431697-81-2)
Recommended Standards
- 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-(hydroxymethyl)picolinamide (CAS 1380310-94-0)
- Myristyl stearate (CAS 17661-50-6)
- (2Z)-2-(4-Bromobenzenesulfonyl)-3-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]prop-2-enenitrile (CAS 1025666-41-4)
- 2-Tetradecylhexadecanoic Acid Ethyl Ester (CAS 86302-97-8)
- Nicotinamide Impurity 14 (CAS CATO-C4X-200014)
- Paracetamol EP Impurity N (CAS 3070-86-8)
- Tetrabenazine Impurity 64 (CAS 282721-32-8 (non-labelled))
- 1-(Piperazin-1-yl)ethanamine (CAS 141656-32-8)
- 2-[1-(4-Chlorophenyl)-1H-pyrazole-4-carbonyl]phenyl furan-2-carboxylate (CAS 956326-47-9)
- Tetrakis[(R)-(-)-[(1R)-1-(4-bromophenyl)-2,2-diphenylcyclopropanecarboxylato]dirhodium(II) Rh2(R-BTPCP)4 (CAS 1345974-62-0)
- 6-Chloro-2-cyclopropyl-5-methylpyrimidin-4-amine (CAS 852061-78-0)
- 2-(Hydroxymethyl)benzo[d]oxazole-7-carbonyl chloride (CAS 1803830-13-8)
- 2-(Methylamino)pyrimidine-4-carbonitrile (CAS 1314904-96-5)
- Neuropeptide S (human) (CAS 412938-67-1)
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