Lorazepam Impurity 8 CAS 2848-96-6
| CAS No. | 2848-96-6 |
| Molecular Formula | C17H12Cl2N2O3 |
| Molecular Weight | 363.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C17H12Cl2N2O3, Lorazepam Impurity 8 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 363.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Lorazepam Impurity 8 (CAS 2848-96-6) is a certified pharmaceutical impurity reference standard with the molecular formula C17H12Cl2N2O3 and a molecular weight of 363.19 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lorazepam Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H12Cl2N2O3 |
| Molecular Weight | 363.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lorazepam Standards
- Lorazepam Impurity 19 (CAS CATO-C4X-104119)
- Lorazepam Impurity 20 (CAS CATO-C4X-104120)
- Lorazepam impurity 9 (CAS CATO-C4X-10419)
- Lorazepam Impurity 18 (CAS CATO-C4X-104118)
- Lorazepam-D4 (CAS 84344-15-0)
- Lorazepam Impurity 14 (CAS CATO-C4X-104114)
- Lorazepam Impurity 15 (CAS CATO-C4X-104115)
- Lorazepam-13C2,15N (CAS 907200-04-8)
Recommended Standards
- tert-Butyl 3-iodo-5-methyl-6,7-dihydropyrazolo[1,5-a]pyrimidine-4(5H)-carboxylate (CAS 2770271-24-2)
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- Tert-butyl 3-iodo-2-methyl-6,7-dihydropyrazolo[1,5-a]pyrimidine-4(5H)-carboxylate (CAS 2306269-57-6)
- Dimethyl 2-(bromomethyl)-[1,1'-biphenyl]-4,4'-dicarboxylate (CAS 1186048-29-2)
- Olopatadine Impurity 11 (CAS 56427-76-0)
- Lurasidone Impurity 69 (CAS CATO-C4X-102869)
- Apixaban Impurity 78 (CAS CATO-C4X-108878)
- 4-(2-Cyanoethoxy)benzonitrile (CAS 69333-41-1)
- N1,N1'-(1,4-Phenylene)bis(N4-(4-aminophenyl)benzene-1,4-diamine) (CAS 189000-38-2)
- 2-(Allyloxy)-2-methylpropan-1-ol (CAS 1202883-04-2)
- ((3R,4S)-3-methylpyrrolidine-3,4-diyl)dimethanol hydrochloride (CAS 1217643-22-5)
- Isavuconazole Impurity 87 (CAS 4072-67-7)
- 3-Phenyl-1-(quinoxalin-2-yl)propan-1-one (CAS 885275-42-3)
- Steroidogenesis-Activator Polypeptide (rat) (H-8855.0500) (CAS 108563-23-1)
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