Pyrimethamine Impurity 6 CAS 2856-63-5
| CAS No. | 2856-63-5 |
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pyrimethamine Impurity 6.
CATO supplies Pyrimethamine Impurity 6 (CAS 2856-63-5), a pharmacopoeial impurity reference standard (molecular formula C8H6ClN, MW 151.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Pyrimethamine Impurity 6 (C8H6ClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pyrimethamine Standards
- Pyrimethamine EP Impurity C (CAS 140-53-4)
- Pyrimethamine EP Impurity A (CAS 55474-40-3)
- Pyrimethamine Impurity 3 (CAS 3275-44-3)
- Pyrimethamine Impurity 1 (CAS 772-79-2)
- Pyrimethamine (CAS 58-14-0)
- Pyrimethamine EP Impurity D (CAS 55474-41-4)
- Pyrimethamine-D3 (CAS 1189936-99-9)
- Pyrimethamine Impurity 4 (CAS 91284-15-0)
Recommended Standards
- 4-(chloromethyl)-3-fluoro-pyridine (CAS 1060802-36-9)
- Letrozole Impurity 38 (CAS 874-86-2)
- 2-chloro-4-fluoro-3-methyl-pyridine (CAS 1227496-67-4)
- Letrozole Impurity 30 (CAS 64407-07-4)
- Prednisone Impurity 1 (CAS CATO-C4X-16941)
- Teprenone impurity 36 (CAS CATO-C4X-208136)
- Iomeprol Impurity 4 (CAS 2068038-50-4)
- 2-(Octyldisulfanyl)ethyl acrylate (CAS 2130960-87-9)
- 1806744-83-1 3-Hydroxy-4-(trifluoromethoxy)-2-(trifluoromethyl)pyridine-6-carboxaldehyde (CAS 1806744-83-1)
- 4-Chloromethyl-3-fluoro-benzonitrile (CAS 345903-03-9)
- 1-(4-(Trifluoromethyl)benzyl)guanidine (CAS 14629-39-1)
- (4-Chloro-3-(trifluoromethyl)phenyl)methanol (CAS 65735-71-9)
- 3-(4-Aminophenyl)-1,1-dimethylurea (CAS 70826-90-3)
- Tau Peptide (74-102) (Exon 3/Insert 2 Domain) trifluoroacetate salt (CAS 1322695-34-0)
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