Letrozole Impurity 38 CAS 874-86-2
| CAS No. | 874-86-2 |
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Letrozole Impurity 38 (CAS 874-86-2), a pharmacopoeial impurity reference standard (molecular formula C8H6ClN, MW 151.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Letrozole Impurity 38 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 151.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Letrozole Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Letrozole Standards
- Letrozole Impurity 29 (CAS 612-13-5)
- Letrozole Impurity 30 (CAS 64407-07-4)
- Letrozole Impurity N2 (CAS 84545-14-2)
- Letrozole Impurity 17 (CAS 112809-27-5)
- Letrozole Impurity 22 (CAS 876728-37-9)
- Letrozole Impurity 23 (CAS 876316-41-5)
- Letrozole Impurity 4 (CAS 112809-25-3)
- Letrozole Impurity 15 (CAS 74231-65-5)
Recommended Standards
- Pyrimethamine EP Impurity C (CAS 140-53-4)
- Pyrimethamine Impurity 6 (CAS 2856-63-5)
- Loratadine Impurity 69 (CAS 1529-41-5)
- 4-(chloromethyl)-3-fluoro-pyridine (CAS 1060802-36-9)
- Piribedil Impurity 17 (CAS CATO-C4X-281317)
- Dasatinib Impurity 6 (CAS CATO-C4X-16076)
- Anastrozole Impurity 15 (CAS 2469244-33-3)
- 4-(2,2,2-Trifluoroethoxy)phenol (CAS 129560-99-2)
- 4-amino-5,6-dimethyl thieno(2,3-d)pyrimidin-2(1H)-one hydrochloride (CAS 1033366-59-4)
- 6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (CAS 1210-56-6)
- (17β)-3,17-Bis[(1-oxopentyl)oxy]-estra-1,3,5(10)-trien-6-one (CAS 1350468-78-8)
- 4-Methylquinoline-3-carboxamide (CAS 109391-70-0)
- 3-Azabicyclo[3.1.0]Hexan-6-amine (CAS 208837-84-7)
- Liraglutide(13-31)TFA Salt (CAS CATO-C4X-19929)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com