Minocycline Impurity 43 CAS 28698-94-4
| CAS No. | 28698-94-4 |
| Molecular Formula | C24H29N5O8 |
| Molecular Weight | 515.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Minocycline Impurity 43 (CAS 28698-94-4, C24H29N5O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Minocycline Impurity 43 (C24H29N5O8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 515.52 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H29N5O8 |
| Molecular Weight | 515.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 5 |
Related Minocycline Standards
- Minocycline Impurity 26 (CAS 149934-16-7)
- Minocycline EP Impurity G (CAS 601455-95-2)
- Minocycline Dehydro Impurity (CAS CATO-C4X-16995)
- Minocycline Impurity 64 (CAS CATO-C4X-169964)
- Minocycline Impurity 67 (CAS CATO-C4X-169967)
- Minocycline Impurity 71 (CAS CATO-C4X-169971)
- Minocycline Impurity 54 (CAS CATO-C4X-169954)
- Minocycline EP Impurity F (CAS 1075240-33-3)
Recommended Standards
- Dabigatran Impurity 12 (CAS CATO-C4X-108912)
- Pemetrexed Impurity 55 (CAS CATO-C4X-172655)
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- Pemetrexed Impurity 57 (CAS CATO-C4X-172657)
- Hydroxychloroquine Impurity 93 (CAS 59127-80-9(free base))
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- 2,6-Dichloro-N'-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]benzohydrazide (CAS 326807-66-3)
- 1-(Cyclopentyloxy)-2,3-difluoro-4-nitrobenzene (CAS 1881332-23-5)
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- 1-[2-(methoxymethyl)phenyl]hexahydropyrimidine-2,4-dione (CAS 1522936-98-6)
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