Verapamil EP Impurity I CAS 2893-91-6
| CAS No. | 2893-91-6 |
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Verapamil EP Impurity I (CAS 2893-91-6), a pharmacopoeial impurity reference standard (molecular formula C26H36N2O4, MW 440.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Verapamil EP Impurity I (C26H36N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 440.58 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- (S)-(-)-Verapamil HCl (CAS 36622-29-4)
- Verapamil EP Impurity J (CAS 67018-85-3)
- Verapamil Impurity 36 (CAS 77326-93-3)
- Verapamil Impurity 37 (CAS 67018-80-8)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil Impurity 39 (CAS 31910-93-7)
- Verapamil Impurity 44 (CAS CATO-C4X-177844)
- Verapamil EP Impurity H (CAS 67018-83-1)
Recommended Standards
- N,N'-Diphenyl-N,N'-di(m-tolyl)-1,4-phenylenediamine (CAS 80223-29-6)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((5,6-dimethyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 761420-54-6)
- AEE 788 (CAS 497839-62-0)
- 4-[(3-Methoxyphenyl)sulfanyl]-2-[(4-methylphenyl)methanesulfonyl]-5,6,7,8-tetrahydroquinazoline (CAS 478246-75-2)
- Everolimus O-Ethyl Impurity (CAS 1704711-12-5)
- Oseltamivir impurity 232 (CAS CATO-C4X-1720232)
- Safinamide Impurity 5 (CAS 690969-16-5)
- 4-(Chloromethyl)-3-(2,6-dichlorophenyl)-5-isopropylisoxazole (CAS 700835-81-0)
- tert-Butyl 4-Hydroxy-3-nitrobenzoate (CAS 273939-22-3)
- N-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)acetamide (CAS 1316225-52-1)
- N-(2-morpholinoethyl)-2,2-diphenylacetamide (CAS 329219-60-5)
- (E)-3-Chloro-2-((2,4-dichlorobenzylidene)amino)-9H-fluoren-9-one (CAS 7151-62-4)
- Sodium 3-iodobenzenesulfonate (CAS 51119-76-7)
- Allo-D-Ile27-Tirzepatide (CAS CATO-CPTD788961)
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