Verapamil EP Impurity H CAS 67018-83-1
| CAS No. | 67018-83-1 |
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Verapamil EP Impurity H (CAS 67018-83-1) is a certified pharmaceutical impurity reference standard with the molecular formula C26H36N2O4 and a molecular weight of 440.59 g/mol.
Structurally, Verapamil EP Impurity H (C26H36N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 440.59 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Verapamil EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- (S)-(-)-Verapamil HCl (CAS 36622-29-4)
- Verapamil EP Impurity J (CAS 67018-85-3)
- Verapamil EP Impurity I (CAS 2893-91-6)
- Verapamil Impurity 36 (CAS 77326-93-3)
- Verapamil Impurity 37 (CAS 67018-80-8)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil Impurity 39 (CAS 31910-93-7)
- Verapamil Impurity 44 (CAS CATO-C4X-177844)
Recommended Standards
- O-Trimethyl GFT-505 (CAS 923978-25-0)
- 2-(Dicyclohexylphosphino)-N,N-bis(1-methylethyl)-1H-indole-1-carboxamide (CAS 1067175-36-3)
- m-PEG3-S-PEG3-Boc (CAS 2055040-96-3)
- 2-(Decylthio)benzyl 2-(9H-purin-9-yl)acetate (CAS 646509-87-7)
- Olaparib Impurity 137 (CAS CATO-C4X-1135137)
- Telmisartan Impurity 28 (CAS 152628-03-0)
- Amlodipine Impurity 103 (CAS 53901-54-5)
- (5-Amino-1-phenyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methanone (CAS 54606-40-5)
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- Letrozole Impurity 10 (CAS CATO-C4X-182910)
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- 4-Bromo-2-chloro-1-benzenesulfonyl Chloride (CAS 351003-52-6)
- 2,2-Difluoro-2-(5-methylpyridin-2-yl)ethan-1-ol (CAS 780769-39-3)
- Insulin Lispro (CAS 133107-64-9)
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