Verapamil Impurity 37 CAS 67018-80-8
| CAS No. | 67018-80-8 |
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil Impurity 37.
CATO supplies Verapamil Impurity 37 (CAS 67018-80-8), a pharmacopoeial impurity reference standard (molecular formula C26H36N2O4, MW 440.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Verapamil Impurity 37 (C26H36N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 440.58 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Verapamil Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | 440.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- (S)-(-)-Verapamil HCl (CAS 36622-29-4)
- Verapamil EP Impurity J (CAS 67018-85-3)
- Verapamil EP Impurity I (CAS 2893-91-6)
- Verapamil Impurity 36 (CAS 77326-93-3)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil Impurity 39 (CAS 31910-93-7)
- Verapamil Impurity 44 (CAS CATO-C4X-177844)
- Verapamil EP Impurity H (CAS 67018-83-1)
Recommended Standards
- N,N'-Diphenyl-N,N'-di(m-tolyl)-1,4-phenylenediamine (CAS 80223-29-6)
- Gadoteridol impurity 36 (CAS CATO-C4X-225736)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((5,6-dimethyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 761420-54-6)
- Trifarotene impurity 22 (CAS CATO-C4X-313222)
- Roxatidine impurity 72 (CAS CATO-C4X-121372)
- Imatinib Impurity 41 (CAS CATO-C4X-106841)
- Troxipide Impurity 26 (CAS 2198252-47-8)
- 1-Oxo-1,3-dihydro-2-benzofuran-4-sulfonyl chloride (CAS 1114822-78-4)
- N-(adamantan-1-yl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetamide (CAS 865658-04-4)
- 4,4'-Dihexyl-2,2'-bithiazole (CAS 180729-92-4)
- N-(Isoxazol-3-yl)-2-(5-(4-methoxyphenyl)isoxazol-3-yl)acetamide (CAS 953255-64-6)
- Vinpocetine Impurity 22 (CAS CATO-C4X-184322)
- AZD 9272 (CAS 327056-26-8)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
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