Levothyroxine EP Impurity C CAS 51-24-1
| CAS No. | 51-24-1 |
| Molecular Formula | C14H9I3O4 |
| Molecular Weight | 621.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levothyroxine EP Impurity C (CAS 51-24-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H9I3O4 and a molecular weight of 621.93 g/mol.
Levothyroxine EP Impurity C (C14H9I3O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, a polycyclic aromatic system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9I3O4 |
| Molecular Weight | 621.93 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
Related Levothyroxine Standards
- Levothyroxine Impurity 16 (CAS 92905-78-7)
- Levothyroxine Impurity 42 (CAS 4618-45-5)
- Levothyroxine Impurity 14 (CAS 3914-31-6)
- Levothyroxine Impurity 17 (CAS 51-26-3)
- Levothyroxine EP Impurity A (CAS 6893-02-3)
- Levothyroxine EP Impurity K (CAS 5817-39-0)
- Levothyroxine EP Impurity K (R-Isomer) (CAS 66701-15-3)
- Levothyroxine Impurity 58 (CAS 176258-87-0)
Recommended Standards
- Liothyronine Impurity N1 (CAS 92151-30-9)
- Hydrochlorothiazide Impurity 28 (CAS CATO-C4X-117728)
- O,o-bis(4-bromo-2,5-dichlorophenyl) phenylphosphonothioate (CAS 50654-88-1)
- Hydrochlorothiazide Impurity 58 (CAS 289907-38-6)
- Goserelin Impurity 26 Acetate (CAS 52434-75-0(free base))
- Tepotinib impurity 27 (CAS CATO-C4X-337427)
- Omeprazole Impurity 36 (CAS CATO-C4X-125536)
- 3-Chloroisoquinoline-6-carbonitrile (CAS 1337880-36-0)
- Cefotaxime Impurity 82 (CAS CATO-C4X-120182)
- (R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-2-methylazetidine-2-carboxylic acid (CAS 1384745-43-0)
- 5-chloro-4-methoxy-pyridin-2-amine (CAS 662117-63-7)
- Imidazo[1,2-b]pyridazine-2-carboxamide (CAS 123531-29-3)
- (3-Fluorophenyl)(4-methoxyphenyl)methanol (CAS 38158-78-0)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
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