Palbociclib Impurity 146 CAS 2955712-44-2
| CAS No. | 2955712-44-2 |
| Molecular Formula | C24H28N8O3 |
| Molecular Weight | 476.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Palbociclib Impurity 146 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Palbociclib Impurity 146 (CAS 2955712-44-2) is a certified pharmaceutical impurity reference standard with the molecular formula C24H28N8O3 and a molecular weight of 476.53 g/mol.
The molecular framework of Palbociclib Impurity 146 (C24H28N8O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H28N8O3 |
| Molecular Weight | 476.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Nitrogen Atoms | 8 |
Related Palbociclib Standards
- Palbociclib Impurity 125 (CAS CATO-C4X-1125125)
- Palbociclib impurity 128 (CAS CATO-C4X-1125128)
- Palbociclib impurity 130 (CAS CATO-C4X-1125130)
- Palbociclib Impurity 121 (CAS 1974279-40-7)
- Palbociclib Impurity 135 (CAS CATO-C4X-1125135)
- Palbociclib Impurity 57 (CAS 2174002-16-3)
- Palbociclib Impurity 108 (CAS CATO-C4X-1125108)
- Palbociclib Impurity 154 (CAS CATO-C4X-1125154)
Recommended Standards
- Dexamethasone Acetate EP Impurity I (CAS 3949-26-6)
- Triamcinolone Acetonide EP Impurity F (CAS 3870-07-3)
- Betamethasone Acetate EP Impurity C (CAS 330157-05-6)
- Apixaban Impurity 2 (CAS 2187409-01-2)
- Darunavir Impurity 29 (CAS 98-74-8)
- Nifedipine EP Impurity B (CAS 50428-14-3)
- Moxifloxacin Impurity 85 (CAS CATO-C4X-107485)
- 5-ethyl-4-methylfuran-2-carboxylic acid (CAS 106949-97-7)
- Methyl 2-aminobut-3-enoate (CAS 70837-21-7)
- 4-Methoxy-2-nitro-biphenyl (CAS 16098-16-1)
- Propan-2-yl 3-phenyl-5-(propan-2-yloxy)-1,2,4-triazine-6-carboxylate (CAS 338956-98-2)
- Methyl 4-(4-fluorophenyl)-4-methylpentanoate (CAS 1707393-59-6)
- 5-Cyclopropoxy-N-methyl-4-nitropyridin-3-amine (CAS 1243376-92-2)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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