Clotrimazole Impurity 21 CAS 29647-82-3
| CAS No. | 29647-82-3 |
| Molecular Formula | C19H15ClO |
| Molecular Weight | 294.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Clotrimazole Impurity 21 (C19H15ClO) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Clotrimazole Impurity 21 (CAS 29647-82-3, C19H15ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H15ClO |
| Molecular Weight | 294.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole EP Impurity A (CAS 66774-02-5)
- Clotrimazole Impurity 16 (CAS 6922-89-0)
- Clotrimazole Impurity 1 (CAS 968-39-8)
- Clotrimazole Impurity 17 (CAS 717109-42-7)
- Clotrimazole Impurity 8 (CAS CATO-C4X-15698)
- Clotrimazole EP Impurity F (CAS 15469-97-3)
- Clotrimazole Impurity 27 (CAS 56153-60-7)
- Clotrimazole Impurity 20 (CAS 27023-37-6)
Recommended Standards
- 2,3-Dibromopropanoyl bromide (CAS 110593-07-2)
- 2,2-Dibromopropanoyl bromide (CAS 51714-76-2)
- 1-Chloro-4-(phenoxy(phenyl)methyl)benzene (CAS CATO-C3D-262255)
- 1,1,3-Tribromoacetone (CAS 3475-39-6)
- Vaborbactam Impurity 2 (CAS CATO-C4X-34772)
- Lenvatinib Impurity 9 (CAS CATO-C4X-11409)
- Bumetanide Impurity 86 (CAS CATO-C4X-198686)
- Fmoc-Lys(2-chloro-Z)-OH (CAS 133970-31-7)
- Hydrido(dimethylphosphinous acid-kP)[hydrogen bis(dimethylphosphinito-kP)]platinum(II) (CAS 173416-05-2)
- tert-butyl 3-(N-hydroxycarbamimidoyl)morpholine-4-carboxylate (CAS 518058-62-3)
- n,n-Dimethyl-1h-pyrazole-4-sulfonamide (CAS 1179901-00-8)
- (1-(4-(Methylthio)benzyl)piperidin-4-yl)methanamine (CAS 1284301-89-8)
- 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isobenzofuran-1(3H)-one (CAS 862081-38-7)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com