Clotrimazole Impurity 8 CAS CATO-C4X-15698
| CAS No. | CATO-C4X-15698 |
| Molecular Formula | C20H17ClO |
| Molecular Weight | 308.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clotrimazole Impurity 8 is closely related to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Clotrimazole Impurity 8 (CAS CATO-C4X-15698), a pharmacopoeial impurity reference standard (molecular formula C20H17ClO, MW 308.80 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Clotrimazole Impurity 8 (C20H17ClO) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Clotrimazole Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H17ClO |
| Molecular Weight | 308.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole Impurity 17 (CAS 717109-42-7)
- Clotrimazole EP Impurity F (CAS 15469-97-3)
- Clotrimazole Impurity 20 (CAS 27023-37-6)
- Clotrimazole Impurity 22 (CAS 59154-29-9)
- Clotrimazole EP Impurity C (CAS 42074-68-0)
- Clotrimazole Impurity 18 (CAS 717109-43-8)
- Clotrimazole EP Impurity A (CAS 66774-02-5)
- Clotrimazole Impurity 16 (CAS 6922-89-0)
Recommended Standards
- 1142214-17-2 3-Chloro-6-[4-(piperidin-1-ylcarbonyl)piperidin-1-yl]pyridazine 9447AC C15H21ClN4O (CAS 1142214-17-2)
- Dehydro desloratadine (CAS 117811-20-8)
- 7-(2-Chlorophenyl)-2-(methylthio)thieno[3,2-d]pyrimidin-4-ol (CAS 1291486-64-0)
- 4-Methoxytrityl chloride (CAS 14470-28-1)
- Erlotinib Impurity 102 (CAS CATO-C4X-1069102)
- Elagolix Impurity 65 (CAS CATO-C4X-206865)
- Grapiprant Impurity 2 TriHCl (CAS CATO-C4X-33892)
- (2,4-Dimethyl-1H-pyrrol-3-yl)methanol (CAS 1082041-74-4)
- 81201-84-5 L-Serine-1-13C L-(l-13C)Serine L-(1-13C)Serine (CAS 81201-84-5)
- (4-Bromo-3-nitrophenyl)methanesulfonyl chloride (CAS 1062066-95-8)
- N-[(4-Chlorophenyl)methyl]-2-oxo-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338782-35-7)
- 7-Bromo-2-methylphthalazin-1(2H)-one (CAS 1437385-48-2)
- 3,4-Diethyl-2-imino-2H-pyrrol-5-amine (CAS 174396-78-2)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com