Clotrimazole Impurity 16 CAS 6922-89-0
| CAS No. | 6922-89-0 |
| Molecular Formula | C19H15ClO |
| Molecular Weight | 294.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Clotrimazole Impurity 16 (CAS 6922-89-0, C19H15ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution, Clotrimazole Impurity 16 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 294.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H15ClO |
| Molecular Weight | 294.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole EP Impurity A (CAS 66774-02-5)
- Clotrimazole Impurity 21 (CAS 29647-82-3)
- Clotrimazole Impurity 1 (CAS 968-39-8)
- Clotrimazole Impurity 17 (CAS 717109-42-7)
- Clotrimazole Impurity 8 (CAS CATO-C4X-15698)
- Clotrimazole EP Impurity F (CAS 15469-97-3)
- Clotrimazole Impurity 27 (CAS 56153-60-7)
- Clotrimazole Impurity 20 (CAS 27023-37-6)
Recommended Standards
- 1-Chloro-4-(phenoxy(phenyl)methyl)benzene (CAS CATO-C3D-262255)
- 2,3-Dibromopropanoyl bromide (CAS 110593-07-2)
- Ethyl 2-acetyl-2-(4-chlorobenzyl)pent-4-enoate (CAS 93026-34-7)
- 2,2-Dibromopropanoyl bromide (CAS 51714-76-2)
- Cefazolin EP Impurity G (CAS 1172998-53-6)
- Baricitinib Impurity 26 (CAS CATO-C4X-226026)
- Irbesartan Impurity 20 (CAS 906474-58-6)
- N-NItroso Clenbuterol (CAS CATO-C4X-199316)
- 2-(Difluoromethyl)-3,6-dimethoxy-4-hydroxypyridine (CAS 1806040-89-0)
- 4-Chlorobenzo[c][1,2]oxaborol-1(3H)-ol (CAS 947162-29-0)
- 2-Benzyl-3-(4-bromo-3-chlorophenoxy)quinoxaline (CAS 478046-95-6)
- 1174847-42-7 3-[(5-Methyl-1H-pyrazol-1-yl)methyl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine MFCD12405271 (CAS 1174847-42-7)
- 4-(Difluoromethyl)-3,5-difluorobenzoic acid (CAS 1807176-85-7)
- Heme iron polypeptide(Hematin) (CAS 14875-96-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com