Chloroquine Diphosphate Hydrate CAS 29791-25-1
| CAS No. | 29791-25-1 |
| Molecular Formula | C18H26ClN3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Chloroquine Diphosphate Hydrate (CAS 29791-25-1), molecular formula C18H26ClN3H3O4P and molecular weight 417.87 g/mol, is a CATO reference standard with documented purity and traceability.
Chloroquine Diphosphate Hydrate (C18H26ClN3H3O4P) contains a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H26ClN3 2*H3O4P |
| Molecular Weight | 417.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloroquine Standards
- Chloroquine-d4 Diphosphate Salt (CAS 1246815-14-4)
- Chloroquine Impurity 1 (CAS 133860-75-0)
- Chloroquine Phosphate (CAS 1446-17-9)
- Chloroquine Dihydrochloride (CAS 3545-67-3)
- Chloroquine Diphosphate (CAS 50-63-5)
- Chloroquine-d5 Diphosphate (CAS 50-63-5 (unlabelled))
- Chloroquine (CAS 54-05-7)
- Chloroquine Phosphate EP Impurity D (Chloroquine USP Related Compound G (Free Form)) (CAS 68121-48-2)
Recommended Standards
- 1,3-Diphenylbenzo[f]chromen-4-ium tetrafluoroborate (CAS 35096-74-3)
- 3-Nitro-N-(4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide (CAS 89541-59-3)
- Oxazole-2,5-dicarboxylic acid (CAS 1449569-97-4)
- 2-(Difluoromethyl)-4-methyl-5-nitropyridine (CAS 1805311-74-3)
- Ethyl 2-(2-nitrophenoxy)acetate (CAS 37682-31-8)
- 1-(Difluoromethyl)-4-methyl-1H-indole (CAS 1602204-87-4)
- 4-Chloro-5-(trifluoromethyl)pyridin-3-ol (CAS 1393546-59-2)
- rel-(2R,4R)-tert-Butyl 4-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate hydrochloride (CAS 1217803-39-8)
- 2-(Naphthalen-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)quinolin-4-amine (CAS 918969-92-3)
- Tau Peptide (74-102) (Exon 3/Insert 2 Domain) trifluoroacetate salt (CAS 1322695-34-0)
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