Chloroquine Dihydrochloride CAS 3545-67-3
| CAS No. | 3545-67-3 |
| Molecular Formula | C18H26ClN3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Chloroquine Dihydrochloride (CAS 3545-67-3), molecular formula C18H26ClN3HCl and molecular weight 356.33 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Chloroquine Dihydrochloride (C18H26ClN3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H26ClN3 2*HCl |
| Molecular Weight | 356.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloroquine Standards
- Chloroquine-d4 Diphosphate Salt (CAS 1246815-14-4)
- Chloroquine Impurity 1 (CAS 133860-75-0)
- Chloroquine Phosphate (CAS 1446-17-9)
- Chloroquine Diphosphate Hydrate (CAS 29791-25-1)
- Chloroquine Diphosphate (CAS 50-63-5)
- Chloroquine-d5 Diphosphate (CAS 50-63-5 (unlabelled))
- Chloroquine (CAS 54-05-7)
- Chloroquine Phosphate EP Impurity D (Chloroquine USP Related Compound G (Free Form)) (CAS 68121-48-2)
Recommended Standards
- 2-(Difluoromethyl)-6-methylpyridine (CAS 1029691-30-2)
- (R)-3-Amino-3-phenylpropan-1-ol hydrochloride (CAS 936499-92-2)
- 4-(hydrazinylmethyl)-N,N-dimethylaniline dihydrochloride (CAS 1909309-06-3)
- 2-((2-(3,4-Dichlorophenyl)-2-oxoethyl)thio)-3-ethyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one (CAS 585563-60-6)
- 5-(4-Fluorophenyl)isoxazole-3-carbonitrile (CAS 1170986-40-9)
- 6-Methoxy-3-(4-piperidinyl)-1,2-benzisoxazole Hydrobromide (CAS 84163-17-7)
- N-((1-(2-Hydroxyethyl)pyrrolidin-2-yl)methyl)-N-isopropylacetamide (CAS 1353963-72-0)
- 1-(Pyrimidin-2-yl)cyclohexan-1-amine (CAS 1339104-44-7)
- 4-(Heptyloxy)benzaldehyde (CAS 27893-41-0)
- Tripeptide-10 citrulline (CAS 960531-53-7)
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