Thiamine /Vitamin B1 Impurity 56 CAS 1153-39-5
| CAS No. | 1153-39-5 |
| Molecular Formula | C12H18N4O2S2 |
| Molecular Weight | 314.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Thiamine /Vitamin B1 Impurity 56 (CAS 1153-39-5, C12H18N4O2S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Thiamine /Vitamin B1 Impurity 56 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 314.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H18N4O2S2 |
| Molecular Weight | 314.43 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Thiamine Standards
- Thiamine Impurity 32 (CAS 52164-53-1)
- Thiamine Impurity 42 (CAS 38655-47-9)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine nitrate EP Impurity E (CAS 299-35-4)
- Thiamine /Vitamin B1 Impurity 55 (CAS 855380-68-6)
- Thiamine Impurity 41 (CAS 92325-11-6)
- Thiamine-13C3 Hydrochloride (CAS CATO-C4X-187317)
- Thiamine Nitrate EP Impurity A (CAS 2380-61-2)
Recommended Standards
- 9-Hydroxynonyl 4-methylbenzenesulfonate (CAS 1146096-85-6)
- Cimetidine EP Impurity H (CAS 74886-59-2)
- 2-Ethylhexyl 3-fluorothieno[3,4-b]thiophene-2-carboxylate (CAS 1401716-01-5)
- N-benzyl-4-methyl-2-(thiophen-3-yl)thiazole-5-carboxamide (CAS 949256-10-4)
- Rabeprazole Impurity 8 (CAS 935260-92-7)
- Hexamidine EP Impurity D (CAS 2514722-87-1)
- Doxycycline EP Impurity C (CAS 6543-77-7)
- 2-Amino-1-methylpyridin-4(1H)-one (CAS 1314956-46-1)
- Methyl N-(3-hydroxyphenyl)-carbamate (CAS 13683-89-1)
- 4-((4,6-Bis(octylthio)-1,3,5-triazin-2-yl)amino)-2,6-di-tert-butylphenol (CAS 991-84-4)
- 6-Phenyl-pyrazinecarbonitrile (CAS 90701-04-5)
- 1-((4-Fluorophenyl)sulfonyl)-2-((1-phenylethyl)thio)-4,5-dihydro-1H-imidazole (CAS 868216-98-2)
- 2-(4-Chlorophenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid (CAS 73684-83-0)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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