Thiamine Impurity 42 CAS 38655-47-9
| CAS No. | 38655-47-9 |
| Molecular Formula | C12H15ClN4S2 |
| Molecular Weight | 314.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Thiamine Impurity 42 (C12H15ClN4S2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Thiamine Impurity 42 (CAS 38655-47-9, C12H15ClN4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Thiamine Impurity 42 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15ClN4S2 |
| Molecular Weight | 314.86 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Thiamine Standards
- Thiamine Impurity 32 (CAS 52164-53-1)
- Thiamine /Vitamin B1 Impurity 56 (CAS 1153-39-5)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine /Vitamin B1 Impurity 55 (CAS 855380-68-6)
- Thiamine nitrate EP Impurity E (CAS 299-35-4)
- Thiamine Impurity 41 (CAS 92325-11-6)
- Thiamine-13C3 Hydrochloride (CAS CATO-C4X-187317)
- Thiamine Nitrate EP Impurity A (CAS 2380-61-2)
Recommended Standards
- Clomipramine (CAS 303-49-1)
- Methyl (R)-2-[(tert-Butyldimethylsilyl)oxy]-2-(3-chlorophenyl)acetate (CAS 153294-01-0)
- Desloratadine-d4 (CAS 381727-29-3)
- 2'-Chloro-2,4,6-triisopropyl-1,1'-biphenyl (CAS 1870911-65-1)
- Cimetidine EP Impurity C Dihydrochloride (CAS 52568-80-6)
- Rotigotine EP Impurity H (CAS 1148154-91-9)
- Clindamycin Impurity 63 (CAS CATO-C4X-134163)
- 1,3,2-Dioxathiolane 2,2-Dioxide (CAS 1072-53-3)
- 2-Amino-2-methylpropane-1,3-diol hemi(4-(1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)-2-isopropyl-5-methylphenyl phosphate) (CAS 68991-93-5)
- N-Phenylquinolin-6-amine (CAS 70682-98-3)
- 3-Chloro-5-methyl-2-propoxybenzaldehyde (CAS 883517-89-3)
- (1,3-Thiazol-5-yl)methyl 4-(trifluoromethyl)benzoate (CAS 338981-70-7)
- 4-Methyl-5-[(2-methylphenyl)methyl]-1,3-thiazol-2-amine (CAS 1155997-73-1)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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