Liothyronine Impurity 2 CAS 70-78-0
| CAS No. | 70-78-0 |
| Molecular Formula | C9H10INO3 |
| Molecular Weight | 307.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Liothyronine Impurity 2 (CAS 70-78-0, C9H10INO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Liothyronine Impurity 2 (C9H10INO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Liothyronine Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10INO3 |
| Molecular Weight | 307.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Liothyronine Standards
- Liothyronine EP Impurity B (CAS 300-39-0)
- Liothyronine Impurity 5 (CAS 4299-64-3)
- Liothyronine Sodium (CAS 55-06-1)
- Liothyronine Impurity N1 (CAS 92151-30-9)
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- rac-Liothyronine-15N-13C9 (CAS CATO-C4X-21313)
- Liothyronine Impurity 2 (CAS 1217733-23-7)
- Liothyronine EP Impurity A (CAS 51-48-9)
Recommended Standards
- Methyl 2-ethoxy-5-iodonicotinate (CAS 335078-24-5)
- 7-Bromo-1,3-dihydroxy-9h-xanthen-9-one (CAS 100334-97-2)
- Ethyl 4-amino-3-hydroxy-5-iodobenzoate (CAS 2090806-81-6)
- Ethyl 4-(2,6-Dichloro-3-fluorophenyl)-2,4-dioxobutanoate (CAS 1041553-00-7)
- Tirofiban Impurity 117 (CAS CATO-C4X-1254117)
- Suvorexant Impurity 13 (CAS 1149352-55-5)
- Nadifloxacin Impurity 2 (CAS 80076-46-6)
- 2-Azido-2,3-dihydro-1h-indene (CAS 180260-72-4)
- Phloroglucinol Dihydrate EP Impurity L (CAS 626-43-7)
- 3-Iodo-1-methyl-1H-indazole-6-carbonitrile (CAS 1426425-00-4)
- 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2,3,6-tetrahydropyridine hydrochloride (CAS 1427379-12-1)
- N-(3-Amino-4-fluorophenyl)cyclopentanecarboxamide (CAS 926255-16-5)
- (R)-3-Amino-3-(3-chlorophenyl)propanamide (CAS 1307988-10-8)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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