Dabrafenib Impurity 38 CAS 3052138-43-6
| CAS No. | 3052138-43-6 |
| Molecular Formula | C23H20F3N5O3S2 |
| Molecular Weight | 535.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dabrafenib Impurity 38 (CAS 3052138-43-6) is a certified pharmaceutical impurity reference standard with the molecular formula C23H20F3N5O3S2 and a molecular weight of 535.56 g/mol.
The molecular framework of Dabrafenib Impurity 38 (C23H20F3N5O3S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Dabrafenib Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H20F3N5O3S2 |
| Molecular Weight | 535.56 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related Dabrafenib Standards
- Dabrafenib Impurity N2 (CAS 1195767-77-1)
- Dabrafenib Impurity 37 (CAS CATO-C4X-303337)
- Dabrafenib Impurity 9 (CAS CATO-C4X-30339)
- Dabrafenib Impurity 19 (CAS 1907654-22-1)
- Dabrafenib Impurity N7 (CAS 1195768-23-0)
- Dabrafenib Impurity 12 (CAS CATO-C4X-303312)
- Dabrafenib-D9 (CAS 1423119-98-5)
- Dabrafenib Impurity 36 (CAS CATO-C4X-303336)
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