Dabrafenib Impurity 19 CAS 1907654-22-1
| CAS No. | 1907654-22-1 |
| Molecular Formula | C24H21F3N4O3S2 |
| Molecular Weight | 534.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Dabrafenib Impurity 19 (CAS 1907654-22-1), a pharmacopoeial impurity reference standard (molecular formula C24H21F3N4O3S2, MW 534.57 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dabrafenib Impurity 19 (C24H21F3N4O3S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H21F3N4O3S2 |
| Molecular Weight | 534.57 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Dabrafenib Standards
- Dabrafenib Impurity N2 (CAS 1195767-77-1)
- Dabrafenib Impurity 37 (CAS CATO-C4X-303337)
- Dabrafenib Impurity 38 (CAS 3052138-43-6)
- Dabrafenib Impurity 9 (CAS CATO-C4X-30339)
- Dabrafenib Impurity 12 (CAS CATO-C4X-303312)
- Dabrafenib Impurity N7 (CAS 1195768-23-0)
- Dabrafenib-D9 (CAS 1423119-98-5)
- Dabrafenib Impurity 36 (CAS CATO-C4X-303336)
Recommended Standards
- Fluocinolone Acetonide Impurity 17 (CAS CATO-C4X-238117)
- Ceftobiprole (CAS 209467-52-7)
- Fluticasone Impurity 35 (CAS CATO-C4X-165035)
- [dideuterio-[(3S)-5,5-dideuteriomorpholin-3-yl]methyl] N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate (CAS 1330172-72-9)
- Dobutamine Impurity 53 (CAS CATO-C4X-129853)
- Lifitegrast Impurity 117 (CAS CATO-C4X-2409117)
- Dopamine Impurity 30 (CAS 339186-39-9)
- tert-Butyl 3-formyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (CAS 1196147-67-7)
- (2,3-Dimethyl-phenyl)-prop-2-ynyl-amine (CAS 1048921-98-7)
- 1-(2-Chloro-4-fluorophenyl)cyclopentanemethanamine (CAS 771583-25-6)
- 1-Methyl-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole (CAS 73725-25-4)
- 1,1,3-Tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane (CAS 1843-03-4)
- methyl 2-oxo-1H,2H,3H-pyrrolo[3,2-b]pyridine-6-carboxylate (CAS 1190312-75-4)
- Delta-Sleep Inducing Peptide (CAS 62568-57-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com