Loratadine Impurity 18 CAS 31255-57-9
| CAS No. | 31255-57-9 |
| Molecular Formula | C14H11ClN2 |
| Molecular Weight | 242.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Loratadine Impurity 18 (CAS 31255-57-9), a pharmacopoeial impurity reference standard (molecular formula C14H11ClN2, MW 242.70 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Loratadine Impurity 18 (C14H11ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Loratadine Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11ClN2 |
| Molecular Weight | 242.70 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 74 (CAS 31255-58-0)
- Loratadine EP Impurity B (CAS 31251-41-9)
- Loratadine impurity 85 (CAS 3964-84-9)
- Loratadine impurity 86 (CAS 31251-43-1)
- Loratadine Impurity 90 (CAS 133330-72-0)
- Loratadine Impurity 31 (CAS 31255-47-7)
- Loratadine Impurity B (CAS 38093-12-8)
- Loratadine Impurity 68 (CAS 133345-21-8)
Recommended Standards
- 3535-43-1 4-Butoxy-3-methoxybenzoyl chloride MFCD11941019 (CAS 3535-43-1)
- 3-(p-Chlorophenethyl)picolinonitrile (CAS 31255-55-7)
- Paliperidone USP Related Compound C (CAS 130049-82-0)
- tert-Butyl N-[(2-chloropyridin-4-yl)methyl]carbamate (CAS 916210-27-0)
- Pregabalin Impurity 50 (CAS CATO-C4X-131250)
- Flunarizine impurity 37 (CAS 768360-45-8 (free base))
- Tafluprost Impurity 5 (CAS CATO-C4X-21635)
- 4-(2-Methylprop-2-en-1-yl)-5-phenyl-4h-1,2,4-triazole-3-thiol (CAS 123366-08-5)
- (2E)-N-(3,4-Difluorophenyl)-3-[4-(2-methylpropyl)phenyl]prop-2-enamide (CAS 329778-54-3)
- N-Boc-5-bromoindole-2-boronic acid, 97% (CAS 475102-13-7)
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- Revefenacin impurity 89 HCl (CAS CATO-C4X-203189)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com