Loratadine Impurity 90 CAS 133330-72-0
| CAS No. | 133330-72-0 |
| Molecular Formula | C14H12ClNO |
| Molecular Weight | 245.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Loratadine Impurity 90 (C14H12ClNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Loratadine Impurity 90 (CAS 133330-72-0) is a certified pharmaceutical impurity reference standard with the molecular formula C14H12ClNO and a molecular weight of 245.70 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Loratadine Impurity 90 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12ClNO |
| Molecular Weight | 245.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Loratadine Standards
- Loratadine EP Impurity B (CAS 31251-41-9)
- Loratadine impurity 85 (CAS 3964-84-9)
- Loratadine impurity 86 (CAS 31251-43-1)
- Loratadine Impurity 18 (CAS 31255-57-9)
- Loratadine Impurity 74 (CAS 31255-58-0)
- Loratadine Impurity 31 (CAS 31255-47-7)
- Loratadine Impurity B (CAS 38093-12-8)
- Loratadine Impurity 68 (CAS 133345-21-8)
Recommended Standards
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- 3-Bromo-1-butyl-5-nitro-1H-indazole (CAS 1352532-26-3)
- Levomequitazine (CAS 88598-74-7)
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