Loratadine impurity 85 CAS 3964-84-9
| CAS No. | 3964-84-9 |
| Molecular Formula | C14H10ClNO |
| Molecular Weight | 243.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Loratadine impurity 85 (CAS 3964-84-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10ClNO and a molecular weight of 243.69 g/mol.
Based on its molecular formula C14H10ClNO, Loratadine impurity 85 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 243.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Loratadine impurity 85 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10ClNO |
| Molecular Weight | 243.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Loratadine Standards
- Loratadine EP Impurity B (CAS 31251-41-9)
- Loratadine impurity 86 (CAS 31251-43-1)
- Loratadine Impurity 18 (CAS 31255-57-9)
- Loratadine Impurity 74 (CAS 31255-58-0)
- Loratadine Impurity 90 (CAS 133330-72-0)
- Loratadine Impurity 31 (CAS 31255-47-7)
- Loratadine Impurity B (CAS 38093-12-8)
- Loratadine Impurity 68 (CAS 133345-21-8)
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