Mesalazine EP Impurity I CAS 3147-53-3
| CAS No. | 3147-53-3 |
| Molecular Formula | C13H10N2O3 |
| Molecular Weight | 242.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Mesalazine EP Impurity I.
As a process- or degradation-related impurity, Mesalazine EP Impurity I (CAS 3147-53-3, C13H10N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Mesalazine EP Impurity I (C13H10N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Mesalazine EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10N2O3 |
| Molecular Weight | 242.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Mesalazine Standards
- Mesalazine Impurity 28 (CAS 40038-46-8)
- Mesalazine Impurity 53 (CAS CATO-C4X-132453)
- Mesalazine Impurity 45 (CAS CATO-C4X-132445)
- Mesalazine Impurity 55 (CAS CATO-C4X-132455)
- Mesalazine Impurity 47 (CAS 13300-63-5)
- Mesalazine Impurity 54 (CAS CATO-C4X-132454)
- Mesalazine Impurity 50 (CAS CATO-C4X-132450)
- Mesalazine Impurity 30 (CAS 14474-22-7)
Recommended Standards
- Mesalamine Impurity 39 (CAS 136819-59-5)
- Eltrombopag Impurity 42 (CAS 612-87-3)
- Topiroxostat Impurity 48 (CAS 4329-75-3)
- Clonazepam impurity 15 (CAS CATO-C4X-140315)
- EtoricoxiB impurity 16 (CAS 90536-66-6)
- Rimegepant Impurity 15 (CAS 1289024-42-5)
- Cefoperazone EP Impurity A (CAS 73240-08-1)
- 5-Bromo-3-fluoro-2-(3-(trifluoromethyl)-3H-diazirin-3-yl)pyridine (CAS 2231673-45-1)
- 1-{(2'R,3'R)-4'-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-5'-methyl-2',3'-dihydro-2,3'-bifuran-2'-yl}ethanone (CAS 771491-82-8)
- 2,8-Dibromoquinoline (CAS 871507-79-8)
- (E)-2-(4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)thiazol-2-yl)-3-(pyridin-4-yl)acrylonitrile (CAS 866019-89-8)
- 2-Oxo-1-oxa-spiro[4.5]decane-3,4-dicarboxylic acid diethyl ester (CAS 134515-27-8)
- 1-Benzyl-5-(hydroxymethyl)-6-(4-methoxyphenyl)piperidin-2-one (CAS 937604-02-9)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
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