Tranexamic Acid Impurity 12 CAS 31719-77-4
| CAS No. | 31719-77-4 |
| Molecular Formula | C8H7ClO2 |
| Molecular Weight | 170.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 170.59 g/mol gives Tranexamic Acid Impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Tranexamic Acid Impurity 12 (CAS 31719-77-4, C8H7ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tranexamic Acid Impurity 12 (C8H7ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO2 |
| Molecular Weight | 170.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
Related Tranexamic Standards
- Tranexamic Acid Impurity 13 (CAS 85888-81-9)
- Tranexamic Impurity 16 (CAS 1642-81-5)
- Tranexamic Impurity 18 (CAS 2375016-71-8)
- Tranexamic Impurity 24 (CAS CATO-C4X-177124)
- Tranexamic Acid-13C2,15N (CAS 1292837-95-6)
- Tranexamic-d2 Acid (CAS 2714435-89-7)
- Tranexamic Acid (CAS 1197-18-8)
- Tranexamic Acid EP Impurity B (CAS 1197-17-7)
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