Amlodipine Besylate EP Impurity H CAS 318465-73-5
| CAS No. | 318465-73-5 |
| Molecular Formula | C28H29ClN2O8 |
| Molecular Weight | 556.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 556.99 g/mol gives Amlodipine Besylate EP Impurity H distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Amlodipine Besylate EP Impurity H (CAS 318465-73-5, C28H29ClN2O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Amlodipine Besylate EP Impurity H is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 556.99 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H29ClN2O8 |
| Molecular Weight | 556.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity 119 (CAS CATO-C4X-1095119)
- Amlodipine Impurity 137 (CAS CATO-C4X-1095137)
- Amlodipine Impurity 59 (CAS 140171-49-9)
- Amlodipine Impurity 151 (CAS CATO-C4X-1095151)
- Amlodipine Impurity 54 (CAS CATO-C4X-109554)
- Amlodipine Impurity 136 (CAS CATO-C4X-1095136)
- Amlodipine Impurity 98 (CAS CATO-C4X-109598)
- Amlodipine Besylate EP Impurity B (CAS 721958-72-1)
Recommended Standards
- 2-Methoxyethyl 4-(4-chloro-3-nitrophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 503591-66-0)
- Q203, 98% (CAS 1334719-95-7)
- 2-Methoxyethyl 4-(2-chloro-5-nitrophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 503591-64-8)
- Dabrafenib Impurity 11 (CAS CATO-C4X-303311)
- Elobixibat Impurity 30 (CAS CATO-C4X-283830)
- Letermovir Impurity 22 (CAS CATO-C4X-291522)
- Istradefylline Impurity 16 (CAS CATO-C4X-106116)
- Methyl (E)-3-(3-Pyridyl)acrylate (CAS 81124-48-3)
- (2S,3S)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2-(2-methoxypropan-2-yl)-2,3-dihydrobenzo[d][1,3]oxaphosphole (CAS 2227217-22-1)
- tert-butyl (3S)-4-(5-bromo-6-chloro-pyridine-3-carbonyl)-3-methyl-piperazine-1-carboxylate (CAS 2253768-43-1)
- 5-Propyl-2-(4-(trans-4-propylcyclohexyl)phenyl)pyrimidine (CAS 98495-17-1)
- 2,5-Dichloro-4-methylthiophene-3-sulfonyl chloride (CAS 145980-83-2)
- 3,5-Dichloro-N-{4-[(4-fluorobenzenesulfonyl)methyl]phenyl}benzamide (CAS 338398-78-0)
- C-Peptide（dog） (CAS 39016-05-2)
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