Lapatinib Impurity 7 CAS 320337-46-0
| CAS No. | 320337-46-0 |
| Molecular Formula | C21H15ClIN3O |
| Molecular Weight | 487.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Lapatinib Impurity 7 (CAS 320337-46-0, C21H15ClIN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H15ClIN3O, Lapatinib Impurity 7 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 487.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H15ClIN3O |
| Molecular Weight | 487.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 3 |
Related Lapatinib Standards
- Lapatinib Impurity 19 (CAS 320337-48-2)
- Lapatinib Impurity 14 (CAS 697299-82-4)
- Lapatinib Impurity 10 (CAS 231278-84-5)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Lapatinib Impurity 37 (CAS 1268997-70-1)
- Lapatinib Impurity 6 (CAS 231278-25-4)
- Lapatinib Impurity 25 (CAS 231278-20-9)
- Lapatinib Impurity 9 (CAS 1393175-04-6)
Recommended Standards
- Buprenorphine 3-O-Methyl ether (CAS 16524-65-5)
- (2S,3R,4R,5R)-5-(benzyloxymethyl)-4-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-2-(6-methoxy-3-pyridyl)tetrahydrofuran-2-ol (CAS 1583260-08-5)
- 1,5-Dibromo-2,4-diiodobenzene (CAS 96843-23-1)
- (2R,3R,4R,5R)-5-(benzyloxymethyl)-4-[tert-butyl(dimethyl)silyl]oxy-3-methoxy-2-(6-methoxy-3-pyridyl)tetrahydrofuran-2-ol (CAS 1583260-09-6)
- Ropivacaine EP Impurity E (CAS 265120-58-9)
- Aztreonam impurity 91 (CAS 80082-50-4)
- Relugolix Impurity 17 (CAS CATO-C4X-242917)
- (4-(tert-Butyl)pyridin-2-yl)methanamine dihydrochloride (CAS 500716-25-6)
- 2,3,4,5-Tetrafluoro-6-iodoaniline (CAS 1228813-89-5)
- Methyl 2-(1,2,3,4-tetrahydroquinolin-2-yl)acetate (CAS 150535-15-2)
- 1,3-Dichloro-5-fluoro-2-(trifluoromethoxy)benzene (CAS 1417569-27-7)
- 6-Amino-1,3,3-trimethyl-2,3-dihydro-1H-indol-2-one (CAS 120791-60-8)
- 2-Methylhex-5-en-2-amine (CAS 819-45-4)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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