Betamethasone impurity 106 CAS 330157-03-4
| CAS No. | 330157-03-4 |
| Molecular Formula | C22H29BrO5 |
| Molecular Weight | 453.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Betamethasone impurity 106 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Betamethasone impurity 106 (CAS 330157-03-4, C22H29BrO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Betamethasone impurity 106 (C22H29BrO5) contains a flavonoid core, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 453.37 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Betamethasone impurity 106 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H29BrO5 |
| Molecular Weight | 453.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
Related Betamethasone Standards
- Betamethasone 17-Propionate-d5 (CAS CATO-C4X-143735)
- Betamethasone Impurity 42 (CAS 25122-45-6)
- Betamethasone Impurity 111 (CAS CATO-C4X-1437111)
- Betamethasone Impurity 143 (CAS CATO-C4X-1437143)
- Betamethasone Impurity 28 (CAS CATO-C4X-143728)
- Betamethasone impurity 48 (CAS CATO-C4X-143748)
- Betamethasone Impurity 108 (CAS CATO-C4X-1437108)
- Betamethasone impurity 66 (CAS 4735-64-2)
Recommended Standards
- tert-butyl N-[5-bromo-4-(dimethoxymethyl)-2-pyridyl]-N-tert-butoxycarbonyl-carbamate (CAS 2271359-81-8)
- (E)-[(4-Chlorophenyl)methoxy][(2-{[(4-chlorophenyl)methyl]sulfanyl}quinolin-3-yl)methylidene]amine (CAS 478065-88-2)
- 9α-Bromo-16α-methylprednisolone (CAS 26543-61-3)
- 2-(4-Chlorophenyl)-3-((4-chlorophenyl)thio)-N,N-dimethylquinoline-4-carboxamide (CAS 477886-45-6)
- Thioctic acid Impurity 34 (CAS CATO-C4X-152634)
- Posaconazole Impurity 83 (CAS CATO-C4X-120883)
- Phenylbutyrate Impurity 12 (CAS CATO-C4X-258312)
- 7-Hydroxy-3-(4-methylbenzenesulfonyl)-2H-chromen-2-one (CAS 78440-50-3)
- Trietazine (CAS 1912-26-1)
- Ciprofloxacin Ethyl Ester (CAS 105404-65-7)
- 4-(2-(Chloromethyl)oxazol-5-yl)-N,N-dimethylbenzenesulfonamide (CAS 89102-57-8)
- 2-((4-Methoxyphenethyl)amino)-5-nitrobenzonitrile (CAS 785707-50-8)
- 5,8-Dichloro-3,4-dihydroisoquinolin-1(2H)-one, 97% (CAS 1616289-34-9)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com