Crizotinib Impurity 5 CAS 330156-50-8
| CAS No. | 330156-50-8 |
| Molecular Formula | C8H7Cl2FO |
| Molecular Weight | 209.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crizotinib Impurity 5 (CAS 330156-50-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7Cl2FO and a molecular weight of 209.04 g/mol.
Structurally, Crizotinib Impurity 5 (C8H7Cl2FO) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 209.04 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crizotinib Impurity 5 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2FO |
| Molecular Weight | 209.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Crizotinib Standards
- Crizotinib impurity 16 (CAS 877397-65-4)
- Crizotinib Impurity 67 (CAS CATO-C4X-102567)
- Crizotinib Impurity 66 (CAS CATO-C4X-102566)
- Crizotinib impurity 22 (CAS 3469-69-0)
- Crizotinib Impurity 68 (CAS CATO-C4X-102568)
- Crizotinib impurity 19 (CAS CATO-C4X-102519)
- Crizotinib Impurity 70 (CAS CATO-C4X-102570)
- Crizotinib Impurity 73 (CAS CATO-C4X-102573)
Recommended Standards
- Methyl 5-Bromo-4-oxopentanoate (CAS 53856-93-2)
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- 1-Methyl-1,2,3-triazole-5-boronic Acid Pinacol Ester (CAS 1047636-97-4)
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- Cefixime Impurity 17 (CAS CATO-C4X-113917)
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- 5,7-Diphenyl-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 118787-61-4)
- Ethyl 3-iodo-4-(2,2,2-trifluoroacetamido)benzoate (CAS 183989-83-5)
- 1-Cyclohexyl-3-methyl-1,3,5-triazinane-2,4,6-trione (CAS 30243-77-7)
- 2-Bromo-4-nitrobenzaldehyde (CAS 5274-71-5)
- Liraglutide Impurity 14 TFA Salt (CAS CATO-C4X-199214)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com