Amlodipine Impurity 41 CAS 331258-31-2
| CAS No. | 331258-31-2 |
| Molecular Formula | C23H32ClN3O6 |
| Molecular Weight | 481.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Amlodipine Impurity 41 (CAS 331258-31-2) is a certified pharmaceutical impurity reference standard with the molecular formula C23H32ClN3O6 and a molecular weight of 481.97 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Amlodipine Impurity 41 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 481.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C23H32ClN3O6 |
| Molecular Weight | 481.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Amlodipine Standards
- Amlodipine Impurity 139 (CAS CATO-C4X-1095139)
- Amlodipine Impurity 141 (CAS CATO-C4X-1095141)
- Amlodipine Impurity N32 (CAS 103094-30-0)
- Amlodipine Besylate Impurity C (CAS 721958-74-3)
- Amlodipine Impurity 108 (CAS 88150-61-2)
- Amlodipine Impurity 142 (CAS CATO-C4X-1095142)
- Amlodipine Impurity 109 (CAS 2382886-25-9)
- Amlodipine Impurity 116 (CAS CATO-C4X-1095116)
Recommended Standards
- (T-4)-[3-Bromo-5-[(4-bromo-3,5-dimethyl-2H-pyrrol-2-ylidene-κN)phenylmethyl]-2,4-dimethyl-1H-pyrrolato-κN]difluoroboron (CAS 910823-84-6)
- Encorafenib Impurity 3 (CAS CATO-C4X-32493)
- Chlorpromazine ring opening ethyl ester (CAS CATO-C4X-232141)
- 2-(Benzylsulfanyl)-3-[(3-chloro-4-methoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydroquinazolin-4-imine (CAS 477848-72-9)
- Daprodustat Impurity 22 (CAS CATO-C4X-240722)
- Rivaroxaban Impurity 22 (CAS 31166-29-7)
- Pimozide impurity 1 (CAS CATO-C4X-31151)
- Rel-(1R,2S)-1,2-diethynylcyclopropane (CAS 59502-33-9)
- 3-(difluoromethyl)pyrrolidine hydrochloride (CAS 1376176-56-5)
- 2,4-Dimethyl-6-(2-morpholinoethoxy)benzaldehyde (CAS 1215903-35-7)
- Benzyl 3-(((S)-2-amino-N-ethylpropanamido)methyl)piperidine-1-carboxylate (CAS 1354026-23-5)
- (2-(1H-1,2,4-triazol-1-yl)phenyl)methanamine hydrochloride (CAS 869591-75-3)
- Ethyl (E)-3-(benzylamino)but-2-enoate (CAS 21731-13-5)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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