6-Trifluoromethyl-pyrazin-2-ylamine CAS 69816-35-9
| CAS No. | 69816-35-9 |
| Molecular Formula | C5H4F3N3 |
| Molecular Weight | 163.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-Trifluoromethyl-pyrazin-2-ylamine is closely related to a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-Trifluoromethyl-pyrazin-2-ylamine (CAS 69816-35-9) is a high-purity analytical reference standard with the molecular formula C5H4F3N3 and a molecular weight of 163.10 g/mol.
6-Trifluoromethyl-pyrazin-2-ylamine (C5H4F3N3) contains a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Trifluoromethyl-pyrazin-2-ylamine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4F3N3 |
| Molecular Weight | 163.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 4-(Trifluoromethyl)pyrimidin-5-amine (CAS 1092299-22-3)
- 5-(Trifluoromethyl)-1H-pyrrole-2-carbaldehyde (CAS 1367875-88-4)
- 3-(Trifluoromethyl)pyridin-4(1H)-one (CAS 140899-19-0)
- 5-(trifluoromethyl)-1H-pyrrole-3-carbaldehyde (CAS 1803567-44-3)
- 5-(Trifluoromethyl)pyrimidin-4-amine (CAS 1805131-89-8)
- 2-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-71-0)
- 3-(Trifluoromethyl)pyridin-2-ol (CAS 22245-83-6)
- 4-(Trifluoromethyl)pyridine 1-oxide (CAS 22253-59-4)
Recommended Standards
- 6-(Trifluoromethyl)pyridin-3-ol (CAS 216766-12-0)
- 2-Hydroxy-6-trifluoromethylpyridine (CAS 34486-06-1)
- 5-Amino-2-(trifluoromethyl)pyrimidine (CAS 73418-87-8)
- 2-Hydroxy-5-(Trifluoromethyl)Pyridine (CAS 33252-63-0)
- N-(3-nitrophenyl)-N-(phenylsulfonyl)glycine (CAS 117309-44-1)
- 4-[3-(Trifluoromethyl)benzyl]piperidin-4-amine dihydrochloride (CAS 1707361-63-4)
- 2,2,2-Trifluoro-N-(2-oxocyclohexyl)acetamide (CAS 1823251-42-8)
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- 4-(3-Fluoro-5-methylphenyl)butan-2-one (CAS 1502475-76-4)
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- Semaglutide (CAS 910463-68-2)
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