Empagliflozin Impurity N6 CAS 333359-90-3
| CAS No. | 333359-90-3 |
| Molecular Formula | C20H23ClO6 |
| Molecular Weight | 394.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Empagliflozin Impurity N6 (CAS 333359-90-3, C20H23ClO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution, Empagliflozin Impurity N6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 394.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Empagliflozin Impurity N6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H23ClO6 |
| Molecular Weight | 394.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 258 (CAS CATO-C4X-1065258)
- Empagliflozin Impurity 238 (CAS CATO-C4X-1065238)
- Empagliflozin impurity 257 (CAS CATO-C4X-1065257)
- Empagliflozin impurity 222 (CAS CATO-C4X-1065222)
- Empagliflozin impurity 185 (CAS CATO-C4X-1065185)
- Empagliflozin impurity 204 (CAS 1800196-43-3)
- Empagliflozin Impurity 40 (CAS CATO-C4X-106540)
- Empagliflozin Impurity 44 (CAS CATO-C4X-106544)
Recommended Standards
- Amlodipine Impurity N21 (CAS 2170111-18-7)
- N-{6-[4-(6-Chloro-2-pyridinyl)piperazino]-3,5-dicyano-2-pyridinyl}-N,N-dimethyliminoformamide (CAS 339110-72-4)
- Amlodipine Besylate EP Impurity F (CAS 140171-66-0)
- Afatinib Impurity 25 (CAS CATO-C4X-100625)
- Bromfenac Impurity 15 (CAS CATO-C4X-200215)
- Nicergoline Impurity 32 (CAS CATO-C4X-208532)
- Amikacin impurity 32 (CAS CATO-C4X-197732)
- (2,4,6-Trichlorophenyl)hydrazine hydrochloride (CAS 2724-66-5)
- Ethyl 2-(4-chloro-2-fluorophenoxy)acetate (CAS 1716-87-6)
- 1-(2-Chlorophenyl)-2-(3-hydroxypiperidin-1-yl)ethan-1-one (CAS 1338680-65-1)
- 1-(5-Chloro-2-nitrobenzoyl)pyrrolidine (CAS 541542-37-4)
- 3-Chloro-5-isopropyl-1H-1,2,4-triazole (CAS 54671-65-7)
- 2-Bromo-3,6-difluorobenzaldehyde, 97% (CAS 934987-26-5)
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