Empagliflozin impurity 222 CAS CATO-C4X-1065222
| CAS No. | CATO-C4X-1065222 |
| Molecular Formula | C17H18ClIO |
| Molecular Weight | 400.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin impurity 222.
Empagliflozin impurity 222 (CAS CATO-C4X-1065222) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18ClIO and a molecular weight of 400.68 g/mol.
Based on its molecular formula C17H18ClIO, Empagliflozin impurity 222 contains a steroid core, a hydroxyl group, an ether linkage, chlorine/iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 400.68 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18ClIO |
| Molecular Weight | 400.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 257 (CAS CATO-C4X-1065257)
- Empagliflozin impurity 185 (CAS CATO-C4X-1065185)
- Empagliflozin Impurity N6 (CAS 333359-90-3)
- Empagliflozin impurity 258 (CAS CATO-C4X-1065258)
- Empagliflozin Impurity 238 (CAS CATO-C4X-1065238)
- Empagliflozin impurity 190 (CAS CATO-C4X-1065190)
- Empagliflozin Impurity 136 (CAS CATO-C4X-1065136)
- Empagliflozin Impurity 111 (CAS 2194590-02-6)
Recommended Standards
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- Brivaracetam Impurity 121 (CAS CATO-C4X-2007121)
- Cytarabine Impurity 7 (CAS CATO-C4X-20057)
- 1-Pentyl-3-(thiophen-2-ylsulfonyl)-2,3-dihydro-1H-imidazo[4,5-b]quinoxaline (CAS 848060-01-5)
- 4-Hydroxypiperidine-1-carbonitrile (CAS 51075-37-7)
- Methyl (2R,4R)-4-((tert-butoxycarbonyl)amino)pyrrolidine-2-carboxylate hydrochloride (CAS 1279038-36-6)
- 5-Bromo-1,4,6-trimethyl-2,3-dihydro-1h-pyrrolo[2,3-b]pyridine (CAS 627098-12-8)
- N-(4-(diethylamino)phenyl)acetamide (CAS 5326-57-8)
- 5-(1-(2,4-Dimethylphenoxy)ethyl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 861434-27-7)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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