Nintedanib Impurity 34 CAS 334952-09-9
| CAS No. | 334952-09-9 |
| Molecular Formula | C9H7NO3 |
| Molecular Weight | 177.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nintedanib Impurity 34.
Nintedanib Impurity 34 (CAS 334952-09-9) is a certified pharmaceutical impurity reference standard with the molecular formula C9H7NO3 and a molecular weight of 177.16 g/mol.
Structurally, Nintedanib Impurity 34 (C9H7NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 177.16 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7NO3 |
| Molecular Weight | 177.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 160 (CAS 7207-35-4)
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 43 (CAS 59276-28-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
- Nintedanib Impurity 68 (CAS 2840-28-0)
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Nintedanib Impurity 67 (CAS 40872-87-5)
Recommended Standards
- Zonisamide Impurity 5 (CAS 4865-84-3)
- Peficitinib Impurity 2 (CAS CATO-C4X-28072)
- Pazopanib Impurity 30 (CAS 1313372-75-6)
- 4-Cyano-2-methoxybenzoic acid (CAS 89469-52-3)
- Fluconazole Impurity 35 (CAS CATO-C4X-101935)
- Fasudil Impurity 23 (CAS CATO-C4X-136523)
- Tedizolid Impurity 19 (CAS CATO-C4X-105419)
- Spiro[chromane-4,1'-cyclopropane]-8-carboxylic acid (CAS 2245322-64-7)
- 2,6-Difluoro-3-nitrobenzimidamide (CAS 1260657-03-1)
- 3-(Aminomethyl)-1-methyl-1H-indazole (CAS 739359-10-5)
- Olanzapine Impurity 28 (CAS CATO-C4X-117828)
- Baloxavir Impurity 141 (CAS CATO-C4X-2108141)
- (2R,3R,4R,5R)-5-(6-(N-Benzoylbenzamido)-9H-purin-9-yl)-2-(hydroxymethyl)-4-((2-nitrobenzyl)oxy)tetrahydrofuran-3-yl benzoate (CAS 64481-95-4)
- Peptide Impurity 82 (CAS 10491-78-8)
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