Nintedanib Impurity 43 CAS 59276-28-7
| CAS No. | 59276-28-7 |
| Molecular Formula | C10H14O3 |
| Molecular Weight | 182.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Nintedanib Impurity 43 (CAS 59276-28-7), a pharmacopoeial impurity reference standard (molecular formula C10H14O3, MW 182.22 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nintedanib Impurity 43 (C10H14O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nintedanib Impurity 43 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H14O3 |
| Molecular Weight | 182.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
Related Nintedanib Standards
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
- Nintedanib Impurity 160 (CAS 7207-35-4)
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Nintedanib Impurity 67 (CAS 40872-87-5)
- Nintedanib Impurity 39 (CAS 3395-81-1)
- Nintedanib Impurity 44 (CAS 3395-80-0)
Recommended Standards
- Phenytoin EP Impurity A (CAS 119-61-9)
- Bifonazole impurity 16 (CAS CATO-C4X-156016)
- Dopamine Impurity 64 (CAS CATO-C4X-190864)
- Tamsulosin Impurity 11 (CAS 3250-73-5)
- Pyronaridine Impurity 8 (CAS 14969-40-5)
- Urapidil Impurity 65 (CAS 2468009-96-1)
- Lornoxicam Impurity 24 (CAS CATO-C4X-201624)
- 5-((Benzo[d][1,3]dioxol-5-ylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 369398-78-7)
- Ym 872 (CAS 210245-80-0)
- 7-Methyl-2-(p-tolyl)-5H-chromeno[2,3-b]pyridin-5-one (CAS 62627-18-3)
- (1-(Thiazol-2-yl)azetidin-3-yl)methanol (CAS 1420881-99-7)
- 5-Bromo-4-chloro-3-indoxyl-alpha-L-arabinofuranoside (CAS 885126-47-6)
- 7-(Trifluoromethyl)-3,3a-dihydro-1H-thiazolo[3,4-a]quinoxalin-4(5H)-one (CAS 1024595-52-5)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com