(3-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethoxy)phenyl)methanol CAS 338409-27-1
| CAS No. | 338409-27-1 |
| Molecular Formula | C19H21ClF3N3O2 |
| Molecular Weight | 415.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (3-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethoxy)phenyl)methanol.
(3-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethoxy)phenyl)methanol (CAS 338409-27-1), molecular formula C19H21ClF3N3O2 and molecular weight 415.84 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, (3-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethoxy)phenyl)methanol is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 415.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21ClF3N3O2 |
| Molecular Weight | 415.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)methyl)-2,4-difluorophenyl)propane-1-sulfonamide (CAS 1021854-28-3)
- [4-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}ethoxy)phenyl]methanol (CAS 338409-36-2)
- 3-chloro-5-[4-({[4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]thio}methyl)phenyl]isothiazole-4-carbonitrile (CAS 662138-29-6)
- 5-Chloro-1-(2-phenoxyethyl)-3-phenyl-2-(trifluoromethyl)-1H-indole (CAS 338966-38-4)
- 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]-1,2-oxazole (CAS 287176-94-7)
- 2-(2-Chloro-5-(phenylsulfonyl)benzamido)benzoic acid (CAS 724440-27-1)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(p-tolyl)-1H-pyrrole-2-sulfonamide (CAS 321433-64-1)
- 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-(phenylsulfanyl)pyrrolidine-2,5-dione (CAS 338772-49-9)
Recommended Standards
- Lenvatinib Impurity 121 (CAS CATO-C4X-1140122)
- 2-(2-Chloropyridin-3-yl)-5,6-dimethyl-1-{[3-(trifluoromethyl)phenyl]methyl}-1H-1,3-benzodiazole (CAS 339101-23-4)
- 5-Methyl-2-oxotetrahydrofuran-3-carbonitrile (CAS 76263-39-3)
- 3-(4-Chlorophenyl)-6,7-diphenyl-2H-oxazolo[3,2-a][1,3,5]triazine-2,4(3H)-dione (CAS 35629-68-6)
- (2-Phenylpropyl)(propan-2-yl)amine (CAS 125453-50-1)
- 1-Cyclobutyl-4,4,4-trifluorobutan-2-amine (CAS 1495011-51-2)
- 3-(4-(3-(4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)piperidin-1-yl)-3-oxopropyl)-3,5-dimethyl-1H-pyrazol-1-yl)propanenitrile (CAS 1197728-20-3)
- 1,5-Dichloro-2-fluoro-3-nitrobenzene (CAS 501644-37-7)
- Gedocarnil (CAS 109623-97-4)
- 5-(2,3-dihydro-1,4-benzodioxine-6-carbonyl)-1-methyl-1H-imidazole (CAS 1557653-00-5)
- Tetraphenylphosphonium thiocyanate (CAS 35171-64-3)
- 4-Methyl-3-(pentan-2-ylamino)benzonitrile (CAS 1247054-94-9)
- 2-Amino-N-((2S)-2-(benzyl(methyl)amino)cyclohexyl)-3-methylbutanamide (CAS 1354024-70-6)
- Semaglutide Impurity 167 (CAS CATO-C4X-2226167)
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