N-(4-chlorobenzyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide CAS 338792-67-9
| CAS No. | 338792-67-9 |
| Molecular Formula | C16H11ClF5NO2 |
| Molecular Weight | 379.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 379.71 g/mol gives N-(4-chlorobenzyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-(4-chlorobenzyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-67-9), molecular formula C16H11ClF5NO2 and molecular weight 379.71 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(4-chlorobenzyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (C16H11ClF5NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-chlorobenzyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H11ClF5NO2 |
| Molecular Weight | 379.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
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Recommended Standards
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- 5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-N-[(1E)-(methoxyamino)methylidene]-4,5-dihydro-1,2-oxazole-3-carboxamide (CAS 338410-28-9)
- 4-(4-Formylphenyl)butanoic acid (CAS 34162-05-5)
- 1-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid (CAS 2092678-51-6)
- 3,5-Dichloro-N-(((3S,4R)-3-fluoropiperidin-4-yl)methyl)benzamide (CAS 918333-96-7)
- 1-Bromo-5-difluoromethoxy-4-fluoro-2-nitrobenzene (CAS 1805525-46-5)
- [(1H-Benzotriazol-1-yl)methyl]triphenylphosphonium Chloride (CAS 111198-09-5)
- (3-Cyano-[1,2,4]triazol-1-yl)-acetic acid tert-butyl ester (CAS 1252436-79-5)
- 2-((2-Cyano-3-methylbutan-2-yl)amino)-2-oxoethyl 4-((2-oxopyrrolidin-1-yl)methyl)benzoate (CAS 871672-87-6)
- 4-(2,5-Difluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326809-10-2)
- 2-(1-(Cyclopropylmethyl)piperidin-4-yl)-1-(4-fluorophenyl)ethan-1-one (CAS 135135-80-7)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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