Afatinib Impurity 55 CAS CATO-C4X-100655
| CAS No. | CATO-C4X-100655 |
| Molecular Formula | C14H7ClFN5O5 |
| Molecular Weight | 379.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Afatinib Impurity 55.
Afatinib Impurity 55 (CAS CATO-C4X-100655) is a certified pharmaceutical impurity reference standard with the molecular formula C14H7ClFN5O5 and a molecular weight of 379.69 g/mol.
Based on its molecular formula C14H7ClFN5O5, Afatinib Impurity 55 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 379.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Afatinib Impurity 55 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H7ClFN5O5 |
| Molecular Weight | 379.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib impurity 42 (CAS CATO-C4X-100642)
- Afatinib Impurity 73 (CAS CATO-C4X-100673)
- Afatinib Impurity 62 (CAS CATO-C4X-100662)
- Afatinib Impurity 2 (CAS 314771-76-1)
- Afatinib Impurity 21 (CAS 402855-03-2)
- Afatinib Impurity 58 (CAS CATO-C4X-100658)
- Afatinib Impurity 90 (CAS CATO-C4X-100690)
- Afatinib Impurity 60 (CAS CATO-C4X-100660)
Recommended Standards
- tert-Butyl 4-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate (CAS 1337533-82-0)
- (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine 864466-71-7 (CAS 864466-71-7)
- 1-(3-Bromobenzoyl)-4-(3-chlorophenyl)piperazine (CAS 333345-81-6)
- N-(4-chlorobenzyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-67-9)
- Hybutimibe Impurity 6 (CAS CATO-C4X-25056)
- R-Letermovir Impurity 61 (CAS CATO-C4X-291561)
- Remdesivir Impurity 24 (CAS CATO-C4X-210024)
- 2-(4-Chlorophenyl)-5-methyloxazole-4-carboxamide (CAS 51655-77-7)
- Potassium (4-Cyanophenyl)trifluoroborate (CAS 850623-36-8)
- 2-(4-Bromophenoxy)benzonitrile (CAS 330793-13-0)
- (4-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)piperidin-1-yl)(5-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (CAS 1210510-93-2)
- 2-Amino-4-chloro-5-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile (CAS 1227053-98-6)
- 2-(2-Methoxyethoxy)-1-methyl-4-nitrobenzene (CAS 1881329-29-8)
- D-[His]1-Semaglutide (CAS CATO-C4X-222652)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com