Ketoprofen Impurity 43 CAS 34040-63-6
| CAS No. | 34040-63-6 |
| Molecular Formula | C9H9ClO2 |
| Molecular Weight | 184.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 184.62 g/mol gives Ketoprofen Impurity 43 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ketoprofen Impurity 43 (CAS 34040-63-6) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9ClO2 and a molecular weight of 184.62 g/mol.
Ketoprofen Impurity 43 (C9H9ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9ClO2 |
| Molecular Weight | 184.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
Related Ketoprofen Standards
- Ketoprofen Impurity 46 (CAS 713-36-0)
- Ketoprofen Impurity 49 (CAS 620-83-7)
- Ketoprofen Impurity 36 (CAS 872091-00-4)
- Ketoprofen Impurity 38 (CAS 64379-72-2)
- Ketoprofen Impurity 44 (CAS 131019-17-5)
- Ketoprofen Impurity 63 (CAS 146257-39-8)
- Ketoprofen Impurity 112 (CAS 42872-32-2)
- Ketoprofen Impurity 62 (CAS 333991-43-8)
Recommended Standards
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- 2-(Aminomethyl)-6-ethoxybenzo[d]oxazole (CAS 1806303-14-9)
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