Sorafenib Impurity 12 CAS 343247-69-8
| CAS No. | 343247-69-8 |
| Molecular Formula | C8H6ClF3N2O |
| Molecular Weight | 238.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C8H6ClF3N2O, Sorafenib Impurity 12 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 238.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Sorafenib Impurity 12 (CAS 343247-69-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H6ClF3N2O and a molecular weight of 238.59 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Sorafenib Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3N2O |
| Molecular Weight | 238.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Sorafenib Standards
- Sorafenib Impurity 15 (CAS CATO-C4X-112415)
- Sorafenib Impurity 61 (CAS 284462-78-8)
- Sorafenib EP Impurity A (CAS 284462-37-9)
- Sorafenib Impurity 54 (CAS 1153328-25-6)
- Sorafenib Impurity 27 (CAS 757251-59-5)
- Sorafenib Impurity 45 (CAS 46843-47-4)
- Sorafenib Impurity 30 (CAS 1012058-77-3)
- Sorafenib Impurity 59 (CAS 284462-80-2)
Recommended Standards
- 916420-92-3 3-Methoxy-5-(trifluoromethyl)benzoyl chloride MFCD09025410 (CAS 916420-92-3)
- 90931-40-1 2-Chloro-N-[5-(trifluoromethyl)pyridin-2-yl]acetamide MFCD11867372 (CAS 90931-40-1)
- Moxifloxacin Impurity N41 (CAS 172602-81-2)
- 85630-83-7 [3-(Trifluoromethyl)phenoxy]acetyl chloride DTXSID60521241 (CAS 85630-83-7)
- (S)-Prothioconazole Impurity N1 (CAS 4819-36-7)
- Atorvastatin Impurity 140 (CAS CATO-C4X-1132140)
- Nintedanib Impurity 20 (CAS 2734676-68-5)
- 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperidine-3-carboxylic acid,2HCl (CAS 1431963-32-4)
- ETHYL 2-(DIMETHYLAMINO)-2-(THIOPHEN-2-YL)ACETATE (CAS 1007885-50-8)
- (2-aminophenyl)(1-piperidinyl)methanone 2-(1-piperidinylcarbonyl)aniline 39630-25-6 (CAS 39630-25-6)
- 2-Fluoro-4-methylbenzylamine hydrochloride (CAS 1214334-14-1)
- 5-Bromo-1-methyl-2,3-dihydroindole (CAS 99848-78-9)
- Methyl 1-ethylpyrrolidine-2-carboxylate (CAS 107599-40-6)
- Anti-Inflammatory Peptide 1 (CAS 118850-71-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com